RAD 140 / Testolone Beginners Guide: Dosage, Side Effects, and Real Reviews

There are plenty of substances in the world that can help us enhance our body beyond its natural abilities, but there are very few of them that don’t come with immense risks. SARMs are one of these few substances, as their risks are relatively mild, and the potential rewards outweigh them for most users.

Out of every SARM on the market, RAD 140 is one of the most notorious, as it’s the most powerful one available. This, naturally, arouses curiosity about it, and we decided to put together this guide so that our readers can know everything about RAD-140 before determining whether or not to use it.

Introduction to RAD 140 / Testolone

What is RAD 140

RAD 140 (also known as Testolone) is a SARM, which stands for Selective Androgen Receptor Modulators, and they bind themselves to such receptors all around your body. Androgens are a natural hormone in the body, and they’re a form of steroid. Examples of the ones that your body produces include testosterone, androstenedione, and more.

You’ve likely heard of how more testosterone can improve your gains when building muscle, and that is broadly true for SARMs as well. The vast difference between SARMs and natural hormones is the extent to which they can improve your results when working out.

Different kinds of SARMs will have more or less powerful effects, and some will facilitate muscle growth in different ways. While some SARMs help you bulk up, others, like RAD-140, will help you generate more lean muscle. So what makes RAD140 so exceptional compared to other SARMs?

RAD-140 was discovered in 2011, and it’s one of the newest SARMs on the market because of that. Radius Health first developed the compound, and that’s where the RAD in its name comes from. Testolone was initially developed as a treatment for breast cancer, and it’s still being studied for that application.

Along with being so recent, RAD-140 is also one of the most potent supplements of its type, and it’s only rivaled by LGD-4033 (Ligandrol) when it comes to creating lean muscle mass.

Molecular structure of RAD 140

What are the main benefits of using RAD 140?


Here are the key advantages of RAD 140 in their order of discovery:

  1. A possible treatment for breast cancer
  2. It improves the body’s ability to build muscle
  3. RAD-140 can help you lose weight and change your physique

Increase in Muscle Mass

The main reason why people use SARMs is so that they can improve their results when they’re trying to build muscle, and that’s also true for Testolone. The main advantage of RAD-140 is that it provides the user with effects like steroids with none of the severe side effects and the lack of prohibited status.

While there hasn’t been a human study conducted to see whether RAD-140 affects muscle mass, a study with monkeys determined that lean muscle mass increased after nearly a month of use. This, along with the experiences of users, demonstrates that RAD140 can significantly increase muscle gain.

Breast Cancer Treatment

The initial goal when Radius was developing RAD-140 was to treat breast cancer, and its results so far have been impressive. Specific forms of breast cancer are vulnerable to hormones, including AR+ and ER+, and since RAD-140 affects those hormone receptors, it has potential as a treatment.

Studies show that RAD 140, in specific, is capable of slowing down the growth of breast cancer. RAD-140 works so well because of its suppressive nature, and the reduction in estrogen sensor production can help starve the cancer of the resources that it needs to keep growing.

Improved Cerebral Health

Due to the close link between androgens and brain health, it comes as no surprise that SARMs are also capable of keeping your grey matter in good shape. There are many benefits to increased androgen supply to the brain, including reduced risk of Alzheimer’s, improved brain cell growth, and sharper memory.

Androgens like Testolone can even help protect your system from neurotoxins. Unconfirmed reports have mentioned that RAD-140 users have seen more regular sleep patters. Whether this is due to the direct effects of the supplement or the positive side-effect of another benefit is unknown.

Weight Loss

Since SARMs like RAD-140 reduce body fat, it’s common for users to lose weight when using them. Keep in mind that it will also help increase your muscle generation. Your overall weight may not change as drastically as you expect, though you’ll be able to alter your physique more noticeably.

A study on monkeys even determined that RAD140 can help improve your cholesterol, resulting in a healthier cardiovascular system.

Does RAD 140 cause side effects, and if so which ones?

Side Effects

While SARMs like Testolone are a little more stable than pure testosterone, they can still cause many of the same side-effects. Men can experience tenderness or even swelling around their nipples, while women may notice hair growth in unusual areas, most of the time, these effects end when consumption of RAD 140 ends.

Hair loss is another possibility, especially for men, and RAD-140 can also cause testosterone-like mood swings or even anxiety. If you notice any of these effects, stop taking RAD-140 immediately to figure out whether or not it is the source of your issue in the first place.

Testosterone Suppression

RAD 140 is the most suppressive SARM on the market (LGD is a close second). This can result in some complications. Keep in mind that suppression won’t affect every user the same way, as everyone’s body is made differently and will react accordingly.

When you experience testosterone suppression, your body isn’t able to produce testosterone at a natural rate because of the SARMs that it has grown used to. While RAD140 is meant to minimize the effects of suppression, its high potency means that it’s inevitable for some users to experience it.

Suppression will typically hit you part-way through your cycle, and most people start feeling it around week 4 or 5. There are several different effects related to suppression, and you may have some, or you may have all of them. The most common feeling is persistent tiredness.

Other problems that are caused by suppression include depression and reduced sex drive. Headaches are relatively common for people suffering from testosterone suppression. In rare cases, you may even find yourself suffering from insomnia.

Never Studied with Humans

One of the most significant downsides to RAD 140 is that it hasn’t yet been sufficiently tested with human beings. While there has been a lot of animal testing with this substance, there are a few critical differences between monkeys and humans that can tell us a lot more about how this supplement works.

Full-scale clinical tests with human beings are starting, though few of them have published results. Also, keep in mind that most of the studies are centered around the drug’s ability to fight breast cancer, as that’s a more urgent concern than RAD 140’s muscle growth properties.

Minor Side Effects

As with other supplements, you can expect to experience some minor side effects when you use RAD-140. They can include nausea, and if it progresses to vomiting, then you should stop taking the supplement. Due to the nature of hormones, your sex drive can also be affected adversely by RAD140.

Keep in mind that you’ll be able to reverse any changes to your sex drive within a few weeks of the end of your dosage schedule. You can speed up your return to normal by engaging in Post-Cycle therapy, and we’ll provide some advice about how to do that later on in the guide.

Which SARM is stronger: RAD 140 or Ostarine?

RAD 140 vs Ostarine

RAD 140 is often compared to Ostarine (Enobosarm), which is one of the most popular SARMs on the market. One of the main reasons why Ostarine is so powerful is because it has seen comparatively more testing than many of the other supplements in its same category.

The most significant difference between Ostarine and RAD-140 is that the former is specialized for fat reduction. On the other hand, Testolone is designed to build muscle. While they both do the same thing, each of these supplements has a specialty in either fat reduction or muscle growth.

Read the full writeup about RAD 140 vs Ostarine

Increased Vascularity

One of the main differences between RAD-140 and other SARMs is that it will make your muscles look more veiny. If you’re going for more of a vascular aesthetic, then this can ensure that your muscles don’t look as “soft” as they would when using other supplements.

Keep in mind that this vascular texture won’t be permanent, and you’ll have to maintain it. Since you will inevitably stop using RAD-140, you may notice that it will eventually get harder to keep your muscles looking veiny, though it’s possible to maintain the look with some extra work.

Higher Aggression

One of the leading steroid side-effects that people try to avoid when opting for SARMs is having to cope with mood swings and unpredictable aggression. Since RAD 140 is stronger than other SARMs, it will also make you more aggressive, though it will be a more controllable kind of aggression.

This will make it easier for you to reach your workout goals, as you’ll be able to challenge the feeling into gains. Along with a stronger method of action, RAD-140 will also leave you more motivated to go and work out when compared to other kinds of SARMs.

RAD 140 vs LGD 4033

These two SARMs are both popular options for bulking cycles. In a lot of ways, they are very similar, but there are some key differences.

I actually wrote an entire blog post comparing RAD 140 and LGD 4033, so I’d suggest reading it if you are deciding between the two.

Where to find RAD 140 for sale: Updated for 2023

Buy RAD 140

If you want to try out RAD-140, you’ll have to know where to get it from, and there are plenty of websites that have it in stock.

In America, most customers can find it for sale online and have it delivered directly to their door. Keep in mind that vendors will not officially label the substance as being sold for human consumption, as the FDA has not yet regulated SARMs. Instead, they are sold for research purposes.

You typically won’t be able to find SARMs over the counter, so you’ll want to be sure that you find a reputable vendor online.

💡 Top RAD 140 Sources in 2024

Looking for pure Testolone? Buy high purity RAD 140, YK 11, MK 677 and LGD 4033 from one of the stores in the Verified Sources list.

Make Sure You Get it From the Right Seller

There are a few reasons why you should be careful about who you buy your RAD-140 from. The least of your worries is having the shipment take much longer to arrive than advertised. If you’ve chosen a particularly lousy seller, you may never receive a supplement or ever see your money again.

However, an even more severe risk when buying SARMs is not getting the product that you paid for. Some of the most disreputable vendors on the market will sell you dangerous and untested Androgens instead of RAD-140 or whichever SARM you paid for, as it won’t cost them as much to produce.

Since the market is unregulated, then it’s hard to determine whether or not you’re paying for the real thing. The best way to ensure that your SARMs are legitimate is to always purchase them from vendors who have proven themselves to be reputable to the community as a whole.

Also, be sure that the company which is producing the SARMs has good feedback from its users. Whenever you try to purchase SARMs online, always check reviews and other feedback from customers to be sure that you’ve chosen the best product and the right place to buy it from.

How much RAD 140 does it take to see results?


The most crucial part of using RAD-140 is knowing how to dose it properly, and this will often take trial and error on your part. However, there are a few guidelines that you should follow so that you can speed up the process, as you’ll have a limited time before you need to take a rest period.

If you’ve never taken SARMs before, then you should stick to a moderate dosage to see how the supplement affects you first. Since RAD 140 is so much stronger than other kinds of androgens, you’ll want to play it safe so that you don’t end up worsening any potential side-effects.

To this end, first-timers should do a 5 mg RAD 140 dosage per day. Experienced bodybuilders who have used things like RAD-140 before can feel free to use between 10 and 20 mg per day to get the results that they desire. If you’re a high-intake user who is highly experienced, 30 mg per day should be your maximum.

Keep in mind that women should use less RAD-140, as it has the potential to affect them more than men. For women who are using it for the first time, between 3 and 5 mg of the supplement per day should be enough to see results. If that doesn’t work, up the dosage to 10 mg per day.

The typical RAD140 cycle is between 8 to 12 weeks long, but if you’re starting off, you shouldn’t exceed 10 weeks. Beginners can shorten their cycle to less than 8 weeks, though this will also reduce the effects of the RAD-140, as it won’t have as much time in which it can take action.

This supplement also features relatively high bioavailability, with your body being likely to absorb 70% of it when you consume it orally. Keep in mind that this was tested with monkeys as there is insufficient scientific literature about the effects of RAD140 on humans.

The Importance of Dosing Safely

Setting your dosage too high when using RAD140 can have a host of adverse effects. The most minor problem with using too much RAD-140 is that you’ll reach the limit of what it can do for you when you get to the higher dosages. Exceeding that will simply mean that you’re wasting the supplement.

Using too much RAD-140 can have the opposite effect when compared to what you expect, as it will amplify the side-effects and do nothing to improve its results. Even users who previously had no side effects will begin to experience them if they start using too much RAD140.

To figure out how much of a dosage you’ll need and determine a safe one, you should get your bloodwork done before you start doing supplements like these. This will let you know how much your HPTA will suppress the substance, and it will also tell you how much natural testosterone you already have.

Most of the side effects of substances like RAD-140 will be the result of too many androgens in your system. A high level of testosterone means that it will take a smaller dosage for problems to start, as you’ll be adding androgens to a hormonal system that is already flush with them.

Half Life

The half-life of RAD 140 is a subject of much debate because of the lack of concrete knowledge about it, though most will estimate that it’s between 15 and 20 hours. This will allow you to dose it once a day without any of it going to waste, allowing you to maintain a regular dosing schedule.

Can you stack RAD 140 with other SARMs?


Since RAD 140 is so much more potent than other supplements of its type, you won’t see it being stacked with other SARMs very often. When it does get stacked with other things, it’s usually to make up for some of RAD-140’s weaknesses. (Note: We have a full guide on stacking RAD 140 here)

RAD-140’s increased potency means that it will typically affect your system a little more harshly than other kinds of SARMs. Some users prefer to mix RAD-140 with Ostarine in a stack, as this helps shorten the recovery period without compromising any of the results when it comes to muscle mass.

Stacking Testolone with Ostarine will also allow you to get the best of both worlds, as the former will build up your muscle while the latter will cut down on your body fat. If you’re looking for an extremely powerful stack that will be guaranteed to give you results, try mixing RAD with LGD 4033. Check out our SARMs bulking stack to learn more about that.

For users who are trying to improve their endurance, we’d recommend stacking RAD140 with Cardarine. You can also stack RAD140 with Ibutamoren, and if you aren’t getting results by stacking it with SARMs, then you can even combine it with a steroid such as Primobolan.

Is RAD 140 safe to use or is it hepatoxic?

Safety Profile

If you’re planning on using RAD140, you’ll first have to make sure that you’re not at risk because of any potential interactions between the supplement and an existing condition. If you have natural hormone imbalances, then you’ll be much more likely to experience side effects while using RAD-140 like water retention.

The genetic coding of your androgen receptors will also play a role in how your body reacts to RAD140, and any mutations may nullify its effects. On the other hand, some mutations can even amplify the effects of RAD-140, meaning you’ll have to take a much smaller dose for the same results.

Post-Cycle Therapy

To ensure that you don’t suffer from any long lasting issues, you’ll have to take it upon yourself to perform post-cycle therapy. While it may sound intimidating, post-cycle therapy just means that you’re using additional supplements to let your body return to its natural state.

The duration of PCT will depend on how long you used SARMs. For longer cycles, you’ll want to continue therapy for four weeks. If your cycle was on the shorter end of the spectrum, then you can typically get away with two to three weeks of PCT. Read our guide on How to PCT After RAD140.

Clomid and Nolvadex are the two most common supplements that are used during PCT. Keep in mind that these are just guidelines and that the results will depend on your system and how it reacts to these supplements.

Should RAD-140 Be the First SARM You Try?

If you’ve never used SARMs before, then you may want to try something a little less potent than RAD140 for your first attempt. By trying out a weaker SARM first, you may find that you don’t even need to use such powerful SARM to get the results that you desire in the first place.

If you buy RAD140 and have a negative experience with it, then you also likely won’t want to try any other kinds of SARMs. While other supplements are capable of causing harmful side-effects, few of them will affect you on the same level as RAD-140.

FAQ and final say on Testolone


When should I take RAD 140?

Dosage timing is not important, but for best results you should aim to re-dose every 12 hours. If you’re taking 10mg a day, take 5mg in the morning and 5mg at night.

How long until RAD 140 kicks in?

You will begin to experience the anabolic effects of RAD 140 in as quickly as a week after starting your cycle. Muscle building effects tend to become apparent around two to three weeks in.

Do I need a PCT after taking RAD 140?

While it’s not necessary, I do recommend a PCT for RAD 140 since it is one of the more suppressive SARMs. An over the counter PCT supplement containing D-Aspartic Acid is a good choice if you can’t get your hands on Nolvadex.

RAD 140 is one of the most effective SARMs on the market, though that can also make it more intimidating than the rest of the pack. We hope that this guide has been able to tell you everything that you need to know to plan your cycle, and we hope that you get the results that you’re looking for. If you have any questions, feel free to drop them in the comments section below!

Chris Jackson
Chris Jackson

Chris Jackson, co-founder of Sarms.io, is a renowned fitness blogger, physique model, and evolutionary bioscience researcher specializing in SARMs (Selective Androgen Receptor Modulators). His extensive work, characterized by cutting-edge research and practical training advice, has made Sarms.io a leading source for accurate, credible information on performance enhancers. With a dedication to improving the understanding and application of SARMs in optimizing human performance, his contributions have not only expanded public awareness but also shaped the conversation around these substances. Chris's pursuit of knowledge and commitment to sharing it continue to inspire many in their fitness journeys.

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