MK677, also known as Ibutamoren, is a non-peptide growth hormone secretagogue that stimulates the release of growth hormone and insulin-like growth factor 1 (IGF-1) in humans [1]. It binds to the ghrelin receptor, which is present in the brain and other tissues, and increases the secretion of growth hormone [1][3]. MK677 has been shown to have positive effects on body composition, increasing lean body mass and decreasing fat mass, as well as improving bone density and muscle strength [1]. It has also been suggested to have cognitive-enhancing effects, potentially contributing to the modulation of senile cognitive decline [2]. However, more research is needed to confirm these effects. MK677 has been well-tolerated in clinical trials, with few reported side effects [1].
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