SR9009 is a man-made compound that acts like a catalyst for the nuclear receptor called REV-ERBα. [1] In animal studies, SR9009 has shown some promising effects such as helping with weight management and exercise [2]. One of the interesting properties of SR9009 is its ability to reduce heart damage and improve survival after a heart attack, thanks to its anti-inflammatory properties [3]. Plus, it was found to protect heart cells from damage caused by doxorubicin, a type of chemotherapy drug, by reducing cell death, maintaining normal cell shape, promoting healthy mitochondria function, and reducing oxidative stress in H9c2 cells and C57BL/6 mice [4]. SR9009 can shield against brain damage caused by insufficient blood flow by activating the Nrf2 pathway, which plays a key role in protecting against oxidative damage [8].

SR9009 Beginners Guide: A Comprehensive Review of Stenabolic by

CAS: 1379686-30-2
Molecular Weight: 437.941 g/mol
Chemical formula: C20H24ClN3O4S
Chemical name: ethyl 3-[[(4-chlorophenyl)methyl-[(5-nitrothiophen-2-yl)methyl]amino]methyl]pyrrolidine-1-carboxylate
Type: Rev-ErbA agonist


  • Boosts endurance and exercise capacity
  • Promotes fat loss and improved metabolism
  • Enhances muscle recovery and repair
  • May have positive effects on sleep patterns


  • Poor oral bioavailability, requiring alternative administration methods
  • Limited human research and long-term safety data

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Sports Technology Labs SR9009

Sports Technology Labs

30ml of SR9009 solution at 10mg/ml. Use code sarmsdotio for 15% off your entire purchase at STL!
Stenabolic from Chemyo

Chemyo Best Value

50ml of liquid SR9009 solution at 10mg/ml. Use code sarmsdotio for 10% off your entire purchase at Chemyo!
Behemoth Labz injectable SR9009

Behemoth Labz [Injectable]

10ml ampule containing 64mg per ML = 640mg total. Use code BHM31 for 10% off your entire purchase at Behemoth Labz!
Paradigm Peptides SR 9009 / Stenabolic

Paradigm Peptides Capsules

60 capsules at 10mg each = 600 mg total
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You can view the full list of verified sources here


  1. Sulli, Rommel, Wang, Kolar, Puca, Saghatelian, … & Panda (2018). Pharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence. Nature, 7688(553), 351-355.
  2. Dierickx, Emmett, Jiang, Uehara, Liu, Adlanmerini, … & Lazar (2019). SR9009 has REV-ERB–independent effects on cell proliferation and metabolism. Proc. Natl. Acad. Sci. U.S.A., 25(116), 12147-12152.
  3. Stujanna, Murakoshi, Tajiri, Xu, Kimura, Qin, … & Aonuma (2017). Rev-erb agonist improves adverse cardiac remodeling and survival in myocardial infarction through an anti-inflammatory mechanism. PLoS ONE, 12(12), e0189330.
  4. Zou (2023). Pharmacological Activation of Rev-erbα Attenuates Doxorubicin-Induced Cardiotoxicity by PGC-1α Signaling Pathway. Cardiovascular Therapeutics, (2023), 1-12.
  5. Xu, Zhang, Zheng, Tan, Xiong, Yi, … & Yang (2022). SR9009 inhibits lethal prostate cancer subtype 1 by regulating the LXRα/FOXM1 pathway independently of REV-ERBs. Cell Death Dis, 11(13).
  6. Luo, Song, Qi, Tien, Li, Xu, … & Zhang (2022). REV-ERB is essential in cardiac fibroblasts homeostasis. Front. Pharmacol., (13).
  7. Li, Song, Tien, Qi, Graves, Nasiotis, … & Zhang (2022). SR9009 improves heart function after pressure overload independent of cardiac REV-ERB. Front. Cardiovasc. Med., (9).
  8. Sheng (2023). Rev-erbα agonist SR9009 protects against cerebral ischemic injury through mechanisms involving Nrf2 pathway. Front. Pharmacol., (14).
  9. Hu, Zhang, Cao, Jiang, Liu (2022). SR9009 Regulates Acute Lung Injury in Mice Induced by Sepsis. Canadian Respiratory Journal, (2022), 1-12.