GW501516 , also known as Cardarine, is a synthetic agonist of peroxisome proliferator-activated receptor β/δ (PPARβ/δ) [8]. It has been shown to have various effects on human cells, including promoting endothelial cell proliferation and angiogenesis [1], changing lipid/glucose metabolism and gene expression in human skeletal muscle cells [2], preventing the down-regulation of AMPK caused by a high-fat diet in the liver and amplifying the PGC-1α-Lipin 1-PPARα pathway leading to increased fatty acid oxidation [3], and switching fuel preference from glucose to fatty acids in isolated rat skeletal muscle [7]. GW501516 has also been shown to negatively modulate cell migration and invasion of cancer cells [4], and to have an apoptotic effect on invasive bladder cancer cells [8]. In addition, GW501516 has been found to increase the regenerative capacity of human endothelial progenitor cells by stimulating biosynthesis of tetrahydrobiopterin [6], and to improve the inflammatory state in the kidney [5]. Finally, GW501516 has been shown to reduce liver fat content and increase fatty acid oxidation in dyslipidemic subjects with central obesity [9].
Everything you need to know about Cardarine in 2023: A Beginners Guide by

CAS: 317318-70-0
Molecular Weight: 453.498 g/mol
Chemical formula: C21H18F3NO3S2
Chemical name: 2-(4-((2-(4-(trifluoromethyl)phenyl)-5-methylthiazol-4-yl)methylthio)-2-methylphenoxy)acetic acid
Type: PPARδ (peroxisome proliferator-activated receptor delta) agonist


  • Enhances endurance and stamina
  • Boosts fat loss and metabolism
  • Improves cardiovascular health
  • Supports muscle preservation during cutting


  • May cause liver damage if abused
  • Potential cancer risk at high doses

Cardarine For Sale

Navigate through our curated list of GW 501516 Cardarine sources below. Rely on our expertise as we guide you in harnessing the endurance and fat-burning advantages of Cardarine. Pursue your fitness ambitions with the confidence of having the industry’s most reputable providers by your side.

Cardarine capsules from Biaxol Supplements

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60 capsules dosed at 10mg each. Use code sarmsio for 10% off your entire order!
Sports Technology Labs Liquid Cardarine

Sports Technology Labs

30ml of liquid Cardarine solution at 20mg/ml. Use code sarmsdotio for 15% off your entire purchase at STL!
Paradigm Peptides Cardarine

Paradigm Peptides

60 capsules at 10mg each = 600mg total
Cardarine from Chemyo

Chemyo Great Value

50ml of liquid GW 501516 solution at 10mg/ml. Use code sarmsdotio for 15% off your entire purchase at Chemyo!
Behemoth Labz liquid GW-501516

Behemoth Labz

Use code BHM31 for 10% off your entire purchase at Behemoth Labz!
600mg Liquid Cardarine solution from They're Back!

Pre-orders are live at Use code christopher10 to save 10% off your entire order.

You can view the full list of verified sources here


  1. Piqueras, Reynolds, Hodivala-Dilke, Alfranca, Redondo, Hatae, … & Bishop-Bailey (2007). Activation of PPARβ/δ Induces Endothelial Cell Proliferation and Angiogenesis. ATVB, 1(27), 63-69.
  2. Krämer, Al-Khalili, Guigas, Leng, Garcia-Roves, Krook (2007). Role of AMP Kinase and PPARδ in the Regulation of Lipid and Glucose Metabolism in Human Skeletal Muscle. Journal of Biological Chemistry, 27(282), 19313-19320.
  3. Barroso, Rodríguez-Calvo, Serrano-Marco, Astudillo, Balsinde, Palomer, … & Vázquez-Carrera (2011). The PPARβ/δ Activator GW501516 Prevents the Down-Regulation of AMPK Caused by a High-Fat Diet in Liver and Amplifies the PGC-1α-Lipin 1-PPARα Pathway Leading to Increased Fatty Acid Oxidation. Endocrinology, 5(152), 1848-1859.
  4. Elie-Caille, Lascombe, Péchery, Bittard, Fauconnet (2020). Molecular and nanoscale evaluation of N-cadherin expression in invasive bladder cancer cells under control conditions or GW501516 exposure. Mol Cell Biochem, 1-2(471), 113-127.
  5. Magliano, Bringhenti, Souza-Mello (2016). GW501516 Ameliorates A Fructose-Induced Inflammation Independent of AT1r Downregulation in Kidney. Nuclear Receptor Research, (3).
  6. He, Smith, Lu, Joyner, Katusic (2011). Activation of Peroxisome Proliferator-Activated Receptor–δ Enhances Regenerative Capacity of Human Endothelial Progenitor Cells by Stimulating Biosynthesis of Tetrahydrobiopterin. Hypertension, 2(58), 287-294.
  7. Brunmair, Staniek, Dörig, Szöcs, Stadlbauer, Marian, … & Fürnsinn (2006). Activation of PPAR-δ in isolated rat skeletal muscle switches fuel preference from glucose to fatty acids. Diabetologia, 11(49), 2713-2722.
  8. Péchery, Fauconnet, Bittard, Lascombe (2016). Apoptotic effect of the selective PPARβ/δ agonist GW501516 in invasive bladder cancer cells. Tumor Biol., 11(37), 14789-14802.
  9. Ooi, Watts, Sprecher, Chan, Barrett (2011). Mechanism of Action of a Peroxisome Proliferator-Activated Receptor (PPAR)-δ Agonist on Lipoprotein Metabolism in Dyslipidemic Subjects with Central Obesity. The Journal of Clinical Endocrinology & Metabolism, 10(96), E1568-E1576.