LGD-4033, also known as ligandrol or anabolicum, is a selective androgen receptor modulator (SARM) that binds to androgen receptors in the body, leading to anabolic effects on muscle and bone tissue [1]. LGD-4033 has been shown to increase bone mineral density, bone formation, and bone strength in preclinical models [4]. It is commercially available as a supplement product and is becoming increasingly popular among athletes due to its promising anabolic effects [5]. However, its use is banned by WADA [5]. LGD-4033 has been shown to increase skeletal muscle mass without commensurate improvements in muscular strength and function [3]. It has also been investigated in clinical trials for increasing bone strength in healthy young men [4]. The presence of a cyano group in LGD‐4033 instead of a nitro group improves the half‐life of the compound [7].
| CAS: | 1165910-22-4 |
| Molecular Weight: | 338.25 g/mol |
| Chemical formula: | C14H12F6N2O |
| Chemical name: | 4-[(2R)-2-[(1R)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-yl]-2-(trifluoromethyl)benzonitrile |
| Type: | Selective Androgen Receptor Modulator |
PROS:
- Promotes muscle growth and strength
- Enhances fat loss and body composition
- Increases bone density and durability
CONS:
- May cause temporary testosterone suppression
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