YK11 (also known as Myostine) is a unique selective androgen receptor modulator (SARM) that activates androgen receptors (AR) [1]. Studies show that YK11 induces myogenic differentiation and selective gene regulation, and up-regulates osteoblastic proliferation and differentiation in MC3T3-E1 cells [2][3]. YK11 has also been used as a basis for designing antimicrobial peptides with improved activity and less cytotoxicity [6]. YK11 blocks the N/C-interaction required for the full-agonistic function of wild-type AR, inducing selective AR-target genes owing to the constitutive transactivation potential of AF-1 subdomain in endogenous AR-expressing MDA-MB 453 cells [7].
| CAS: | 1370003-76-1 |
| Molecular Weight: | 430.541 g/mol |
| Chemical formula: | C25H34O6 |
| Chemical name: | (methyl 2-{5-methoxy-5,15′-dimethyl-5′-oxospiro[1,4-dioxolane-2,14′-tetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecan]-6′-en-3-ylidene}acetate |
| Type: | Myostatin Inhibitor |
- Stimulates muscle growth and strength
- Enhances fat loss and body composition
- Commonly stacked with other SARMs / AAS
- Limited research and long-term safety data
- May cause temporary testosterone suppression
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