YK11

YK11 (also known as Myostine) is a unique selective androgen receptor modulator (SARM) that activates androgen receptors (AR) [1]. Studies show that YK11 induces myogenic differentiation and selective gene regulation, and up-regulates osteoblastic proliferation and differentiation in MC3T3-E1 cells [2][3]. YK11 has also been used as a basis for designing antimicrobial peptides with improved activity and less cytotoxicity [6]. YK11 blocks the N/C-interaction required for the full-agonistic function of wild-type AR, inducing selective AR-target genes owing to the constitutive transactivation potential of AF-1 subdomain in endogenous AR-expressing MDA-MB 453 cells [7].

Beginners guide to YK11 by Sarms.io

CAS: 1370003-76-1
Molecular Weight: 430.541 g/mol
Chemical formula: C25H34O6
Chemical name: (methyl 2-{5-methoxy-5,15′-dimethyl-5′-oxospiro[1,4-dioxolane-2,14′-tetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecan]-6′-en-3-ylidene}acetate
Type: Myostatin Inhibitor

PROS:

  • Stimulates muscle growth and strength
  • Enhances fat loss and body composition
  • Commonly stacked with other SARMs / AAS

CONS:

  • Limited research and long-term safety data
  • May cause temporary testosterone suppression

YK11 Myostine For Sale

Discover our distinguished lineup of YK11 sources, handpicked for their exceptional products and trustworthy shipping. Tap into our expertise as we assist you in harnessing the muscle growth and strength-boosting capabilities of YK11. Set forth on your fitness odyssey with the reassurance of the industry’s most reliable providers.

YK11 from Sports Technology Labs

Sports Technology Labs

30ml of YK-11 Myostine solution at 10mg/ml. Use code sarmsdotio for 15% off your entire purchase at STL!
$54.98$59.99
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50ml YK-11 available from the Chemyo store

Chemyo Best Value

50ml of liquid YK11 solution at 10mg/ml. Use code sarmsdotio for 10% off your entire purchase at Chemyo!
$71.9879.99
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Paradigm Peptides YK11

Paradigm Peptides Capsules

60 capsules at 5mg each = 300mg total
$69.00
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S23 Liquid available from Behemoth Labz

Behemoth Labz

Use code BHM31 for 10% off your entire purchase at Behemoth Labz!
$121.98$135.99
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Science.bio Liquid YK11: 300mg - 10mg per ML

Science.bio They're Back!

Pre-orders are live at Science.bio! Use code christopher10 to save 10% off your entire order.
$37.49$50.00
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You can view the full list of verified sources here

References:

  1. Piper, Dib, Putz, Fusshöller, Pop, Lagojda, … & Thevis (2018). Studies on thein vivometabolism of the SARM YK11: Identification and characterization of metabolites potentially useful for doping controls. Drug Test Anal, 11-12(10), 1646-1656.
  2. Kanno, Ota, Someya, Kusakabe, Kato, Inouye (2013). Selective Androgen Receptor Modulator, YK11, Regulates Myogenic Differentiation of C2C12 Myoblasts by Follistatin Expression. Biological & Pharmaceutical Bulletin, 9(36), 1460-1465.
  3. Yatsu, Kusakabe, Kato, Inouye, Nemoto, Kanno (2018). Selective Androgen Receptor Modulator, YK11, Up-Regulates Osteoblastic Proliferation and Differentiation in MC3T3-E1 Cells. Biological & Pharmaceutical Bulletin, 3(41), 394-398.
  4. Kanno, Kusakabe, Saito, Kikkawa, Takahashi, Azumaya, … & Kato (2020). Improved Synthesis and Determination of the Biologically Active Diastereomer of YK11. Molbank, 2(2020), M1125.
  5. Miklos (2019). LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY METHODS FOR THE DETERMINATION OF ANDARINE AND OSTARINE IN RAT SERUM AFTER PROTEIN PRECIPITATION. FARMACIA, 5(67), 772-779.
  6. Kim, Jeong, Kim (2018). Design and Engineering of Antimicrobial Peptides Based on LPcin-YK3, an Antimicrobial Peptide Derivative from Bovine Milk. Journal of Microbiology and Biotechnology, 3(28), 381-390.
  7. Kanno, Hikosaka, Zhang, Inoue, Nakahama, Kato, … & Inouye (2011). (17.ALPHA.,20E)-17,20-[(1-Methoxyethylidene)bis(oxy)]-3-oxo-19-norpregna-4,20-diene-21-carboxylic Acid Methyl Ester (YK11) Is a Partial Agonist of the Androgen Receptor. Biological & Pharmaceutical Bulletin, 3(34), 318-323.
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