RAD 140 VS MK 677 Comparison: Which One Builds More Muscle?

Selective androgen receptor modulators or SARMs are popular in the underground fitness community to help develop lean muscle mass and burn fat. These are banned substances but those in favor of it argue that in limited dosage and cycles, SARMs are effective and not dangerous at all.

Regardless, all SARMs are legally banned for human consumption. They are preferred by bodybuilders because SARMs only interact with the muscles and bones in the body unlike steroids which come with a ton of unwanted side effects and cause damage to the reproductive organs in men and women.

This article will compare RAD 140 (also known as Testolone) and MK 677.

RAD 140MK 677
Common Usage:BulkingBulking
Side Effects:ModerateMinimal
Safe For Women:Not RecommdedYes
Average Dosage:10mg/day20mg/day
PCT Recommended:YesNo
Anabolic Ratio:90:1N/A

What is RAD 140 and what should I know about it?

RAD 140

RAD 140 or Testolone is a relatively new SARM and is sought after by those who want to increase lean muscle mass and enhance performance. This is why it is popular among sportspersons even though the World Anti-Doping Agency or WADA has banned its usage. Nevertheless, these drugs are still being studied as a therapeutic drug to avoid muscle wasting in patients of chronic diseases like advanced cancer, end-stage renal diseases and bone diseases.

It binds to the androgen receptors in the body and is known to leave organs like liver and prostate unaffected. SARMs are notorious for causing testosterone suppression in males, however.

RAD 140 is especially suppressive and should not be used by beginners. Do your homework and make sure you have a plan for when your cycle is over.

This is often countered with post-cycle therapy or PCT. Proponents of SARMs say that when used in cycles with limited dosage, PCT is not required and can be totally avoided. 

What is MK 677 and what should I know about it?

MK 677

Ibutamoren or MK 677 is another popular compound that is available on the black market, like SARMs, as a research product. It is said to promote the secretion of growth hormone and increase insulin growth factor-1 (IGF-1).

It is said to mimic the hormone ghrelin leading to a stimulated growth of hormone release in the brain. It controls the part of the brain that works on appetite, pleasure, mood and cognition.

Ibutamoren decreases the secretion of hormones like cortisol which suppresses the immune system, reduces wound healing capacity and learning capacity.

What are the main differences between RAD 140 and MK 677

Main Differences

  • Testolone increases your cells’ sensitivity to androgens whereas MK 677 works on boosting the growth hormone and insulin growth factor IGF-1
  • RAD 140 is helpful in bulking cycles whereas MK 677 also helps improve bone density in addition to improving muscle mass.
  • RAD 140 is said to work on the lines of muscle recovery whereas MK 677 is said to work on the lines of improving sleep quality.
  • Some experts say RAD 140 might cause liver damage whereas there is no such danger with MK 677.
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What are the main benefits of using MK 677?

MK 677 Benefits

This is a pretty effective substance and is taken in two cycles—bulking and cutting. Beginners are advised to start with 10 mg per day and experienced users can go up to 30 mg per day. The optimal dosage is 25 mg per day.

If you choose to take more than that, know that this leads to a significant increase in IGF-1 levels. That’s your insulin level. MK 677 is more effective in bulking cycles and is often stacked with other SARMs like Testolone by experienced users. Here is a sample of that.

During a bulking cycle, you can take 25 mg of MK 677, 15 mg of RAD 140 and 10 mg of YK11 per day. And during a cutting cycle, take 25 mg of MK 677, 20 mg of ostarine and 30 mg of andarine per day.

These cycles should ideally last anywhere from six to eight weeks. You can go higher than that but you risk tinkering with IGF-1.

What are the main benefits of using RAD 140?

RAD 140 Benefits

RAD 140, on the other hand, is safe when taken up to 20 mg per day. If you are a beginner, start with 15 mg per day. Among women, 5-10 mg per day is the acceptable dosage. You will start to see the results from 0.1 mg of Testolone.

This too can be stacked with other SARMs like MK 677, RAD 140 and cardarine or S-4 for extra benefit. During a bulking cycle, beginners can take 10 mg per day and experienced male users can go up to 20 mg per day. Experienced female users should limit their intake to 10 mg per day.

During a typical cycle, you can take 10 mg Testolone per day for the first eight weeks. You should follow that up with post-cycle therapy or PCT from week nine to week 12. For the next four weeks, let your body recover.

You can extend the recovery period if you feel like your body needs it. During this time period, expect to gain 10 to 15 pounds of muscle mass.

If you want to go for another cycle, you must wait for four to eight weeks so that your testosterone levels can go back to normal.

Final verdict, closing thoughts and conclusion

Our Pick

For beginners who just want to get their feet wet, I suggest MK 677. It’s virtually side effect free and has a lot of other positive benefits for sleep and anti aging.

If you’re an experienced user or you have done SARMs, pro hormones, or steroids before, then go straight for RAD 140. It’s much more powerful for building muscle and is a fun cycle.

You can also take them together. A good stack is 25mg of Ibutamoren and 10mg of RAD 140 a day for 8 weeks. See our RAD 140 Stacks Guide for more on that!


SARMs are considered to be safer alternatives to anabolic steroids. The latter has been associated with high blood pressure, heart diseases causing strokes and heart attacks even in younger users.

Steroids also disrupt hormone production and cause reversible changes in sperm production and low testosterone levels. They also cause irreversible changes like breast development and male-pattern baldness in men.

Now, SARMs are said to steer clear of all these issues. But with most of the evidence about their bodybuilding benefits being anecdotal, there is a very real risk in consuming these products without supervision or proper research.

It is advised that those who are considering taking them do so after thorough research and monitor their progress on a daily basis. It is also crucial to procure high-quality SARMs. You can check out some of them here.

Chris Jackson
Chris Jackson

Chris Jackson, co-founder of Sarms.io, is a renowned fitness blogger, physique model, and evolutionary bioscience researcher specializing in SARMs (Selective Androgen Receptor Modulators). His extensive work, characterized by cutting-edge research and practical training advice, has made Sarms.io a leading source for accurate, credible information on performance enhancers. With a dedication to improving the understanding and application of SARMs in optimizing human performance, his contributions have not only expanded public awareness but also shaped the conversation around these substances. Chris's pursuit of knowledge and commitment to sharing it continue to inspire many in their fitness journeys.

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