SR9009 Oral Bioavailability – Does Stenabolic Need to Be Injected?

 Are you looking to get shredded for the stage or the beach? If you want ripped abs and snaking vascularity, you need some chemical assistance. Typically fitness enthusiasts and bodybuilders turn to dangerous Anabolic Androgenic Steroids (AAS) for their pre-contest and preparation needs. 

Compounds like Anavar, T3, and Clenbuterol are common in cutting cycles, helping the body by increasing fat loss. These oral drugs are effective but come with a host of side effects. From testosterone shutdown to liver damage, AAS, thyroid medications, and asthma drugs come with consequences. 

What if there was a compound offering steroid-like results for your cutting cycle, with a fraction of the side effects and no shutdown? Sound interesting? 

SR9009, or Stenabolic, is the brainchild of professor Thomas Burris of the Scripps Research Institute in collaboration with Ligand. This oral medication stimulates the Rev-Erb protein, influences many biological processes involving glucose and lipid mechanisms. 

What is SR9009 and how does it work?

What is SR9009

SR9009 isn’t a SARM; it’s a Rev-erb-α agonist. Stenabolic lights up a host of biological processes through the binding and activation of the Rev-Erb protein. (1) The action of SR9009 influences lipid and glucose metabolism and macrophages and has a pronounced effect on cellular fat storage mechanisms and circadian rhythms. 

SR9009 gets its most significant feature from its ability to stimulate mitochondria production. As a result, users experience metabolic enhancement in the muscular system. Increases in endurance, strength, and faster fat loss are all common with the use of Stenabolic. 

Research shows lab mice receiving a dose of SR9009 experienced a 50% increase in running speed. The mitochondrial enhancement in the body increases energy levels at a cellular level in the muscular system, resulting in a replenishing effect where new mitochondrion replace old ones as macrophages increase. 

In essence, the effect sees users experience as much as a 5% increase in resting metabolic rate, allowing them to burn body fat whole resting and get an enhanced cutting effect in the gym. The increase in cellular energy enables users to run deep caloric deficits without feeling the same fatigue as natural athletes.

The result is a faster fat loss that’s more effective. SR9009 reduces total lipids in the body, focusing on burning LDL cholesterol for energy. As a result, you get an improved cholesterol profile that heart-healthy. 

Studies on Stenabolic show its effect on triglyceride profiles:

  • Reduce total plasma triglycerides by up to 12%
  • Reduce total cholesterol levels by up to 47%
  • Reduce plasma non-esterified fatty-acids by up to 23%
  • Reduce plasma glucose levels by up to 19%
  • Reduce plasma insulin levels by up to 35%
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This Rev-erb-α agonist produces exactly the opposite result of using AAS. AAS elevates cholesterol levels. However, SR9009 minimizes the production of the heart-happy HDL while increasing levels of the artery-clogging LDL. 

SR9009 also features an anti-inflammatory action on the proinflammatory cytokine IL-6, reducing it by up to 72%. The compound also enhances circadian rhythms, helping you get more therapeutic value out of your sleep. 

That’s good news for bodybuilders, strength athletes, and fitness enthusiasts that need to improve recovery from training-related stress. (2)

Whats the best way to administer SR9009?

Oral vs Injectable

The dose for Stenabolic varies, depending on your experience with the compound. New users will get plenty of benefits out of a dose as low as 10mg per day. Intermediate users can stretch the dose to 20mg per day, while advanced users can tolerate up to 40mg before sides start presenting. 

Advanced users also have the option of stacking SR9009 with other SARMs. Stenabolic works synergistically with other compounds like RAD 140, YK11, and LGD 4033 for an enhanced effect. Stenabolic is also a top choice for PCT, making for a fast recovery from both SARMs and AAS cycles.

It’s important to note that the half-life of Stenabolic is low. You’ll need to take a dose every two to four hours for the compound to remain active in your body. Therefore, you’ll need to dose before bed and immediately on rising to get the best benefit out of this product.

Do you need to inject SR9009 to see results?

Injecting Required?

It’s the short half-life that leads to many of the misconceptions around the dosing of SR9009. A 2013 study in mice also raises concerns around the bioavailability of the compound when taken orally. (3) The pharmacokinetic study shows mice only absorb around 2.2% of the dose through oral administration.

The test involved three REV-ERBα agonists, including SR 9009. The research shows that oral administration results in a 2.2% absorption rate, while injection results in 100% absorption. It’s important to note that the study estimates the bioavailability of the compound in humans at 24%.

Overall, injection using a Dimethyl sulfoxide (DMSO) base to dissolve the SR9009 is the best strategy for injecting SR9009. With subcutaneous injection, the compound reaches the bloodstream in seconds. Still, with a 24% absorption rate, you will get plenty of the drug in your system through oral administration.

The use of DMSO to dilute the raw powder is effective, but you need to know the basic principles and safety around using injectibles. Without the right safety protocols in place, you run the risk of developing an infection that keeps you out of the gym for days or maybe even weeks.

Conclusion & FAQ


SR9009 is a potent Rev-erb-α agonist. Many people confuse it with a SARM, but it’s a completely different compound. Stenabolic is a great choice for adding to a cutting stack, with pronounced effects on fat reduction and enhanced metabolism. 

Stenabolic does not have any suppressive effect on the Hypothalamic Pituitary Testicular Axis (HPTA). As a result, you don’t get the same suppressive effect on your natural testosterone production. SR9009 is not a methylated product, meaning that it has little to no impact on your liver health. With Steanbolic, you get steroid-like results without any sides.

However, there is some discussion around the bioavailability of Stenabolic in the body. Research shows that while the body does not absorb most of your dose, it only takes a small amount to ensure a successful cycle. Injecting SR9009 is not necessary, and it can have disastrous consequences for your health. 

Here are some commonly asked questions regarding injecting SR 9009:

Is it dangerous to inject Stenabolic?

Yes, injecting any form of AAS, including SARMs, peptides, or SR9009 is potentially dangerous to your health. If you don’t know what you’re doing when it comes to subcutaneous and intramuscular injections, you run the infection risk. Infections are dangerous and can lead to life-threatening consequences.

What do I do if I tried to inject Stenabolic and get an infection?

If you do try to inject Stenabolic, and you develop an infection, you’ll notice redness, swelling, and localized pain around the injection site. You’ll need to visit the emergency room at your local hospital for diagnosis and treatment.

The severity of the infection determines the course of treatment. Some infections can become life-threatening, requiring surgery, while others are easy enough to treat with a course of antibiotics. Your doctor will advise you on the best treatment to suit your condition. 

How can I increase the bioavailability of SR9009?

The best way to ensure you get a high-grade product with optimal bioavailability is to buy it from a reputable supplier. Look for products that come with third-party testing. Third-party-testing involves the issuance of certificates of compliance and purity on the batch you’re buying.

Check with the certificate of analysis for the batch date, and make sure you’re buying a fresh batch of SR9009. Stenabolic only has a shelf-life of around 5-years, and some companies might try to offload an old batch to you. The older the batch, the less the efficacy of the product. 

DISCLAIMER: The author and publishing website do not condone the use of SR9009. This drug is not available for human consumption, and we bear no onus of responsibility on your use of SR9009. This information is for research and entertainment purposes only.


Chris Jackson
Chris Jackson

Chris Jackson, co-founder of, is a renowned fitness blogger, physique model, and evolutionary bioscience researcher specializing in SARMs (Selective Androgen Receptor Modulators). His extensive work, characterized by cutting-edge research and practical training advice, has made a leading source for accurate, credible information on performance enhancers. With a dedication to improving the understanding and application of SARMs in optimizing human performance, his contributions have not only expanded public awareness but also shaped the conversation around these substances. Chris's pursuit of knowledge and commitment to sharing it continue to inspire many in their fitness journeys.

1 Comment
  1. There’s plenty of people who safely use injectable medications. Most people don’t go to the emergency room for an infection.

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