Does MK 677 Cause Cancer? Here’s What the Science Says

If you’re hanging around the gym for long enough, you’re bound to hear gym rats talking about MK 677. This compound is sending shockwaves through the fitness and anti-aging industry, thanks to its HGH-like effect on the body.

You might hear of people refer to MK 677 as “Ibutamoren” or “Nutrabol.” This compound is not a SARM or a peptide; it’s a secretagogue. Therefore, it doesn’t have the same adverse health effects when stopping its use.

By using MK 677 in your cycle and PCT, you fast-track your recovery, bringing your natural hormone production back online. Sounds great, right? However, many newbies to MK 677 remain skeptical over the use of this compound.

In this post, we’ll answer the question, “Does MK 677 cause cancer?” We’ll unpack everything you need to know about this compound, including the benefits and side effects.

What Is MK 677 and is it a carcinogen?

What is MK 677

As mentioned, MK 677 is a secretagogue. This compound mimics the hormone ghrelin, increasing the secretion of the growth factors-1 (IGF-1) and human growth hormone (HGH). MK 677 is readily available from online retailers, with selection in pre-pressed tablets or capsules, powder, or injectables.

Ibutamoren binds to the ghrelin receptors (GHSR), stimulating the production of HGH by the brain and pituitary. After activating GHSR, the compound stimulates HGH production, which is present in many regions of the brain.

GHSR is responsible for stimulating cognitive functions like mood, memory, circadian rhythms, and appetite. All these benefits come from an increase in HGH production. MK 677 doesn’t affect other hormone systems in the body, having no effect on cortisol. Therefore, side effects are minimal with its use.

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We all know how powerful HGH is, which is why all the bodybuilders are using it. In 2020 we are seeing it offered more and more frequently from anti aging clinics. You can read our MK 677 vs HGH comparison guide to learn more about the differences.

The neuropeptide, ghrelin, helps with the regulation of the central nervous system (CNS). It’s the hormone that’s responsible for stimulating your appetite. As a result of MK 677 use, you might find that your hunger increases due to the GHSR activity promoted by MK 677.

Ghrelin also helps to regulate energy production and distribution in the body. Ghrelin is a vital factor in metabolism. Affecting the way the body burns body fat, increasing your fat loss efforts. This hormone is also a critical component in managing insulin sensitivity, helping people recover from conditions like obesity and diabetes.

This post is for information and research use only. When experimenting with any secretagogue, peptide, or SARM, go to your doctor for a checkup before starting your cycle.

Why are people using MK 677 in the first place?


There are several benefits to incorporating a MK 677 protocol in your training and diet program. Here are the top advantages of using this compound.

  1. Building Mass:
    • Build muscle and burn fat at the same time! MK 677 keeps you anabolic.
  2. Stop Muscle Wasting
    • Seniors dealing with muscle wasting can use MK 677 to halt the process.
  3. Increase Bone Density
    • Ideal for treatment of people dealing with the loss of bone mass.
  4. Enhance Your Sleep Cycle
    • Experience deep sleep every night, with a therapeutic effect.
  5. Anti-Aging and Longevity
  6. Nootropic Effect
    • Boost cognitive function and enhance your memory.
  7. Treat Growth Hormone Deficiency
    • Boost the natural production of HGH in the body.
  8. Recover Faster and Speed Up Wound Healing
    • Recover your hormonal balance faster after a PED cycle and speed up the healing process for injuries.

What are the main side effects of MK 677?

Side Effects

As with any drug, the use of MK 677 can produce some side effects. However, the sides are not dangerous, and you can resolve most of them with the use of a diuretic.

Using MK 677 increases the levels of water retention in the body. As a result, subcutaneous water builds up around your organs during the first few weeks of use. Some individuals might experience higher blood pressure during the adjustment phase.

The use of a diuretic flushes this subcutaneous water from the tissues, reducing your blood pressure. If you don’t have access to a pharmaceutical-grade script for diuretics, try supplementing with dandelion root extract. The dandelion extract acts as a natural diuretic, relieving the issues with subcutaneous water retention.

The increase in blood pressure also affects the CNS. With extra pressure on tissues, many people find they start to experience tingling skin or numbness in the hands. This side effect occurs due to the subcutaneous water retention pressing down on nerves, causing numbness or tingling sensation.

Some individuals report muscle or joint pain, and that also relates to the nervous system and water retention brought on by using MK 677. Other users report stimulation of appetite, making them feel hungrier than usual. That’s a great side effect for anyone trying to put on mass in the gym.

Managing your dose is the key to eliminating side effects

Dose Management

The presence of sides means that your dose is on the high side. For wellness, hair growth, and anti-aging, a 5mg to 10mg dose is enough to maintain a sustainable long-term protocol. For muscle gain, a dose of 20mg to 25mg is sufficient to keep you in an anabolic state around the clock.

If you notice sides showing up, back off your dose by 5mg, and see if the sides dissipate. Trying to live with the side effects will be uncomfortable, but it’s possible to manage the impact through the intelligent use of diuretics.

Does MK 677 Cause Cancer? Here’s the facts:

Cancer Risk?

Now that you know about the side effects of MK 677 let’s move on to the question in point; Does MK 677 cause cancer? Let’s break it down:

MK 677 is a secretagogue, mimicking ghrelin, causing HGH pulses from the brain and pituitary gland. As HGH levels increase in the body, the liver starts to release igf-1. Igf-1 is responsible for many biological processes, affecting all organ cells, as well as skeletal and muscular tissues.

Igf-1 does not cause cancer. However, if you have a pre-existing tumor, it will increase the growth rate and possibly spread to other biological systems in the body.

Basically, MK 677 → HGH → IGF-1. If you say MK 677 causes cancer, then you have to also claim that both HGH and IGF-1 “cause cancer”. Which we know after decades of research to be untrue.

According to clinical research, Ibutamoren has a good safety profile for use as an HGH stimulant.

A 2-year study of individuals using Ibutamoren with a daily protocol of 25mg, concludes that that “daily administration of MK 677 increases HGH and Igf-1 levels to those of a healthy young adult, without creating any severe adverse side effects.

Furthermore, ghrelin mimetic administration enhances pulsatile HGH secretion, significantly increasing the subject’s fat-free mass while remaining tolerable.

There you have it. MK 677 does not cause cancer growth, but it will allow existing tumors to grow faster. If you’re dealing with the spread of cancer, you need chemotherapy, not MK 677.


Nass, Ralf et al. “Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial.” Annals of internal medicine vol. 149,9 (2008): 601-11. doi:10.7326/0003-4819-149-9-200811040-00003

Lee, Junghun et al. “Effect of the Orally Active Growth Hormone Secretagogue MK-677 on Somatic Growth in Rats.” Yonsei medical journal vol. 59,10 (2018): 1174-1180. doi:10.3349/ymj.2018.59.10.1174

Adunsky, Abraham et al. “MK-0677 (ibutamoren mesylate) for the treatment of patients recovering from hip fracture: a multicenter, randomized, placebo-controlled phase IIb study.” Archives of gerontology and geriatrics vol. 53,2 (2011): 183-9. doi:10.1016/j.archger.2010.10.004

Chris Jackson
Chris Jackson

Chris Jackson, co-founder of, is a renowned fitness blogger, physique model, and evolutionary bioscience researcher specializing in SARMs (Selective Androgen Receptor Modulators). His extensive work, characterized by cutting-edge research and practical training advice, has made a leading source for accurate, credible information on performance enhancers. With a dedication to improving the understanding and application of SARMs in optimizing human performance, his contributions have not only expanded public awareness but also shaped the conversation around these substances. Chris's pursuit of knowledge and commitment to sharing it continue to inspire many in their fitness journeys.

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