MK 677 Side Effects: 3 Most Common Problems Reported

Are you thinking about starting an MK 677 cycle? Ibutamoren is a synthetic compound designed to increase the natural production of Human Growth Hormone (HGH).

Starting your first cycle is an exciting experience. After planning your protocol, its time to start dosing yourself. It’s common for newbies to hesitate when using an anabolic agent like testosterone or MK 677.

Most people dream of the potential results the compound can offer, but the thought of MK 677 side effects keeps them from pulling the trigger.

Yes, it’s true, MK 677 does produce side effects. However, it might surprise you to learn that these sides are not as bad as you think, and vary from person-to-person.

In this post, we’ll unpack everything you need to know about the three most common side effects associated with MK 677 usage.

Is Ibutamoren (MK 677) a SARM or peptide?

What is MK 677

That was a trick question – the reality is that MK 677 is neither a peptide nor a SARM. Ibutamoren has an official classification as a “growth hormone secretagogue.” In other words, taking MK 677 stimulates your natural production of HGH.

Ibutamoren is a special compound, stimulating HGH production along with the Insulin-like growth factor (IGF-1). Many people are skeptical at first when learning about the effects of MK 677, and we can’t blame you.

According to advanced bodybuilders and amateur chemists, MK 677 provides a similar effect on the body to taking genuine HGH. However, the compound doesn’t suppress the body’s natural production of this vital hormone. Therefore, there is no PCT required when coming off your cycle.

There is convincing anecdotal evidence showing that MK 677 acts as a support drug for bodybuilders and athletes using PEDs, like testosterone. MK 677 helps boost the efficacy of the anabolic cycle while helping reduce recovery time in PCT. It can also be used to enhance the quality of your hair, skin, and nails.

Does MK 677 have anti-aging properties?

Properties and Benefits

Anti-aging is a multi-billion dollar industry worldwide. For years, doctors would offer patients with hormonal deficiency treatment with HGH to bring the hormonal system into a balance. As we age, our body starts secreting less growth hormone.

As a result of this drop in HGH production, you start noticing changes to your body. You begin to lose muscle mass, your skin begins to wrinkle, you have less energy, and it’s harder to fall asleep at night. To counter this regression in our physiology, doctors issue HGH therapy to combat the decline. Many people use MK 677 as an HGH alternative.

HGH in small doses of up to 2-IU to 5-IU a day is effective at slowing the signs of aging. HGH therapy is expensive and using real pharmaceutical-grade HGH costs a fortune for a small cycle. Unless you have plenty of money lying around, a long-term protocol is not affordable.

MK 677 boosts the body’s natural production of HGH, mimicking real HGH therapy’s effects on the body. With Ibutamoren, you don’t have the same high-cost of treatment as you do with HGH. MK 677 is affordable and available online from several vendors.

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Cardiovascular Benefits of MK 677

People dealing with a decline in HGH production are at a higher risk of developing heart disease. According to a study by the Internal Medicine at the University of Goteborg in Sweden, both male and female subjects were exposed to HGH therapy, assessing its impact on the cardiovascular system.

The research shows that increased serum levels of HGH have a positive impact on the metabolism and breakdown of LDL lipoprotein, lowering the factors responsible for developing cardiovascular issues like high blood pressure and hypertension.

MK 677 dose with zero side effects

Side Effect Prevention

When people start experiencing side effects relating to MK 677, it’s almost always in the early stages of administration. If you’re a newbie with this compound, begin with a low dose of 10mg per day, split into two doses of 5mg in the morning and evening.

The half-life of MK 677 is 24-hours, and a split dosing approach helps to mimic the natural pulses in your HGH production. Most people run the compound for eight to ten weeks, depending on their goals. When coming off MK 677, there is no hormonal crash like you get with other anabolic compounds like testosterone.

Start your dose at 5mg twice a day, and increase the dose by 5mg every two or three days. Continue with this protocol until you start to experience sides, then back off the dose to find the sweet spot.

Common MK 677 side effects

Side Effects

Let’s look at the three most common side effects involved with MK 677 use. Most of them are harmless and fade after a few weeks into your cycle.

#1 Water Retention and Bloating – The use of MK 677 increases water retention in the body, producing side effects that involve bloating and edema in the limbs’ extremities.

#2 High Blood Pressure – An increase in water retention places more pressure on the heart. As a result, the heart must beat harder, increasing your blood pressure.

#3 Numbness in the Hands – The increase in water retention creates swelling, pushing down on nerves. As a result, you might experience a slight tingling in your hands.

It’s important to note that most of these side effects will dissipate with a prescription diuretic administered by your doctor. If a script is not available, dandelion root extract is a suitable natural diuretic for eliminating the additional water retention in the early stages of your cycle.

Some of the other side effects involved with the use of MK 677 include the following:

  • Swollen joints and edema
  • Tingling skin
  • Joint and muscle pain
  • Lethargy and low energy levels
  • Intense hunger

Do the benefits outweigh the risks for using MK 677?

Benefits vs Risks

As you can see from the details in this post, the presence of side effects from the use of MK 677 is minimal. Provided you split your dose, and don’t go to high with your intake, you’ll feel hardly any sides after the first couple of weeks.

Strong doses can exhibit more sides than smaller doses, and the effect of the drug differs from person-to-person. When deciding to execute any anabolic protocol, it’s important to weigh the risk and reward of using the compound.

Final Thoughts

If you have pre-existing conditions or are new to training, you might get better results with boosting your training and diet, rather than relying on a compound like Ibutamoren.

However, if you’re a seasoned fitness enthusiast or professional, MK 677 is viable to advance your development and training. The use of this compound can give you the edge you need to fast-track your progress and reach your physique goals faster.

This post does not endorse or recommend using MK 677 or any peptide or anabolic compound. The author and website bear no onus of responsibility for readers’ actions and the use of these compounds.

Always consult with your physician before embarking on a MK 677 cycle or any anabolic agent. Your doctor will analyze your bloodwork to determine the state of your hormonal health. This initial consultation acts as the benchmark for your progress in the future.

Taking SARMs, peptides, or secretegogues like MK 677 can have severe adverse effects on your health, especially if you have pre-existing conditions or poor health. Never start any protocol without visiting your doctor first.


Nass, Ralf et al. “Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial.” Annals of internal medicine vol. 149,9 (2008): 601-11. doi:10.7326/0003-4819-149-9-200811040-00003

Chapman, I M et al. “Oral administration of growth hormone (GH) releasing peptide-mimetic MK-677 stimulates the GH/insulin-like growth factor-I axis in selected GH-deficient adults.” The Journal of clinical endocrinology and metabolism vol. 82,10 (1997): 3455-63. doi:10.1210/jcem.82.10.4297

Adunsky, Abraham et al. “MK-0677 (ibutamoren mesylate) for the treatment of patients recovering from hip fracture: a multicenter, randomized, placebo-controlled phase IIb study.” Archives of gerontology and geriatrics vol. 53,2 (2011): 183-9. doi:10.1016/j.archger.2010.10.004

Chris Jackson
Chris Jackson

Chris Jackson, co-founder of, is a renowned fitness blogger, physique model, and evolutionary bioscience researcher specializing in SARMs (Selective Androgen Receptor Modulators). His extensive work, characterized by cutting-edge research and practical training advice, has made a leading source for accurate, credible information on performance enhancers. With a dedication to improving the understanding and application of SARMs in optimizing human performance, his contributions have not only expanded public awareness but also shaped the conversation around these substances. Chris's pursuit of knowledge and commitment to sharing it continue to inspire many in their fitness journeys.

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