S23 Hepatoxicity – Does it Wreck Your Liver for Good?

Fact checked and updated on
S23 liver toxicity: fact or fiction?

So, you’re thinking about running a cycle of S23. You heard the gains are incredible, and it rips fat from your abs in as little as four weeks. Your set to order your S23, but some guy in the gym advises you against it. “It causes liver hepatoxicity,” he says. “Stay away from orals; they all cause liver damage.”

With that sage advice, you suddenly don’t feel as confident about running S23. Does S23 really cause liver hepatoxicity? What is hepatoxicity anyway? The last thing you want is for your liver to pack up halfway through your cycle – that will kill your gains, and complications could take your life.

So, what’s the truth about S23 and liver hepatoxicity? In this post, we’ll give you everything you need to know about S23 and its impact on your liver.

💡 Always buy SARMs from a reputable source like the ones found on the Source List >>

What Is Hepatoxicity?

Hepatoxicity of the liver refers to damage to the organ caused by using an oral supplement or medication. When hepatoxicity occurs, it’s a sign that the liver is already undergoing significant stress, and there is a danger of severe complications arising if you don’t receive immediate treatment.

Liver hepatoxicity is easy for medical professionals to diagnose, and there are several successful treatments to resolve the condition. Fortunately, the liver is a self-generating organ and can reverse mild damage, returning to healthy function.

Common Symptoms of Liver Hepatoxicity

  • A rash on your stomach or the top of your eyelids (petechiae)
  • Stomach pains
  • Vomiting and severe nausea
  • Fatigue and fever
  • A loss of appetite
  • A dark color in your urine
  • Jaundice (a yellowing of the whites of the eyes and the skin)

If you’re experiencing any of these symptoms during any oral cycle, chances are it’s your liver crying out in distress. At this stage, it’s not possible to reverse the effect using OTC methods at home. When pain presents, get to the doctor immediately for a blood test. (1)

Your doctor will expedite the test and treat you based on your symptoms while waiting for the results. Patients in severe pain may require hospitalization to recover. Follow the advice of your doctor, and make sure you don’t use oral compounds again.

Continued liver stress can lead to the development of scar tissue on the liver. This scarring gives way to the onset of cirrhosis of the liver and liver disease.

Anabolic Androgenic Steroids and Liver Toxicity

SARMs get a bad rap from Anabolic Androgenic Steroids (AAS). AAS, like Dianabol, Anavar, and Winstrol, has a methylated structure, increasing liver enzyme production with repeated use. If you don’t control your dose and use the proper cycle support with AAS, it can lead to severe liver injury.

Even injectable AAS can cause severe liver distress. Testosterone and its derivatives like trenbolone, Winstrol, and Masteron all have a toxic effect on the liver. As a result of this established science, many bodybuilders and fitness enthusiasts make the mistake of thinking any oral is going to cause liver damage. (2)

The risk of liver injury associated with AAS is a well-known fact in the bodybuilding and fitness communities. However, SARMs are not AAS, and they have a different risk profile to oral and injectable steroids.

Does S23 Damage Your Liver?

S23 is not a methylated compound with a 17-aa position like Anavar or other oral AAS. Oral AAS requires this methylation to make the drug bioavailable in the liver. However, the drawback of methylated compounds is elevated enzymes and the possibility of hepatoxicity.

S23 does not present this same issue, and users rarely report any problems associated with Liver toxicity on a cycle. However, taking large doses, sacking with other SARMs, or running the compound for extended periods over 8-weeks will have some impact on your liver.

Keep an eye out for the signs of toxicity. Discontinue use of S23 and book a consultation for diagnosis with your doctor.

Can You Stop Liver Hepatoxicity?

You can stop liver toxicity by correct management of your cycle and proper cycle support for the liver. Sticking to your dose is the best strategy to maintain the health of your liver during your cycle.

Beginners taking doses over the 10mg mark are at risk of developing more side effects than experienced users. If you’re testing the waters with S23, make sure you stick with a beginner dose. Using light doses is highly unlikely to cause liver damage, but some studies reporting even 10mg a day of SARMs can have a toxic effect. (3)

Managing your dose is the best way to avoid harm to your liver. The second strategy to prevent toxicity is to use cycle support. Cycle support typically features a supplement with beneficial ingredients that help your liver cope with the stress of processing the drugs.

Look for supplements containing the following ingredients:

  • Silymarin
  • Capparis spinosa
  • Cichorium intybus
  • Mandur bhasma
  • Solanum nigrum
  • Terminalia arjuna
  • Cassia occidentalis
  • Achillea millefolium
  • Tamarix gallica

It’s important to note that S23 has a 12-hour half-life. Therefore, you’ll have to split your dose. Don’t take your cycle support supplement at the same time as your dose. Doing so affects the absorption of the S23. Wait for 4-hours after your dose before taking your cycle support to allow the liver to absorb the S23.

The Verdict – Does S23 Cause Liver Hepatoxicity?

It’s clear that the commotion around the toxicity of S23 and SARMs, in general, is overstated. These compounds do not feature any methylation in the 17a position. Oral AAS, like Anavar and Winstrol V, along with prohormones like superdrol, can cause severe liver distress due to these compounds’ 17a position.

However, some evidence suggests that SARMs may have a toxic effect on the liver, even at small doses. The only way to be sure if you’re dealing with liver problems is through an enzyme test. Your doctor will draw blood and send it to the lad for analysis.

The results show elevations in your liver enzymes, and your doctor recommends treatment based on the extent of your condition. In general, running a liver support product alongside your SARMs cycle is ideal for mitigating the risk involved with using S23.

💊 Which SARM Is Best For Your Goals? Take the quiz:


What's Your #1 Goal?

What's Your Secondary Goal

How Old Are You?


Have You Used Anabolics Before?

Are You Concerned About Side Effects?

SARM Picker Quiz
Your Result: Ostarine
Ostarine is an easy, consistent way to improve your physique. It's mild and can be used for both bulking and cutting. Women can safely use this SARM. New users of SARMs should start here. TEST >>
Your Result: LGD 4033
LGD 4033 is a reliable bulking agent that can help you pack on dry mass. It has very little side effects and can be ran for 8 weeks at a time. It stacks well with other SARMs and can be used to preserve mass while on a cut. Stack with RAD 140 for huge gains or with Cardarine to help melt off some extra fat while you bulk.
Your Result: RAD 140
RAD 140 is arguably the most powerful bulking SARM that currently exists. It does have a higher side effect profile than Ostarine or LGD 4033, but many feel that it is worth it. It is a staple in the advanced bulking stack. You can take it alongside LGD 4033, MK 677, and YK 11 to gain serious amounts of lean body mass in minimal time.
Your Result: Cardarine
Cardarine is not actually a SARM, but it is often referred to as one. It's main ability is to encourage rapid loss of bodyfat and increased endurance. It is a staple for many bodybuilders who are prepping for a show and need to lose excess body fat. Cardarine is best for those who are already doing cardio and want the ability to feel like they can go forever. Since it doesn't have any androgenic effects, females can safely use it.
Your Result: MK 677
This growth hormone secretagogue is a must add to any bulking or cutting stack. MK 677 increases the amount of HGH and IGF-1 that your body produces. Since it works by helping your body increase it's natural levels, you do not need to cycle off MK 677. It has zero notable side effects other than water retention. MK 677 works best when stacked with SARMs such as RAD 140 and LGD 4033 for a bulk, and Ostarine / Cardarine for a cutting cycle. MK 677 really shines in older users who have started to experience lower HGH levels. It can also be used by women safely.
Your Result: SR 9009
SR 9009 is a powerful SARM that has the ability to rapidly melt away excess bodyfat. It works by simulating your body's response to exercise. Users typically result large amounts of weight loss with an increase of body fat. Stack it with Cardarine for the ultimate cutting stack or use with Ostarine to lean bulk.

Almost there! View your results:

S23 Liver Toxicity FAQ

What’s the best liver support for my cycle?

Milk thistle contains a compound known as silymarin. Silymarin is effective at helping the liver cope with stress. This flavonoid has a powerful cleansing effect and its readily available from plenty of online retailers. However, milk thistle comes with low bioavailability, so try to get a liquid format that promises better absorption.

How do I dose my liver support?

Silymarin does such a good job of cleansing the liver that it might take away from your dose’s efficacy if you use it alongside your S23. Therefore, it’s better to wait four hours or so after taking your S23 dose before taking your milk thistle product. This strategy ensures you have stable blood levels of S23 while keeping your liver healthy.

How do I know if my liver is damaged?

There are several signs that your liver is in distress. The most prominent physical response is the onset of “jaundice.” Jaundice turns your skin and the whites of your eyes yellow, signaling an increase in bilirubin in your bloodstream. Consuming milk thistle products might help resolve the situation, but you must stop taking S23 and see your doctor for treatment.

DISCLAIMER: The author of this content and the publishing website are not responsible for your use of SARMs. The information in this article is purely for research and entertainment purposes only. We do not endorse or recommend the use of S23 or any SARMs.

Sources Cited In This Article:

Leave a Comment