S23 Hepatoxicity – Does it Wreck Your Liver for Good?

So, you’re thinking about running a cycle of S23. You heard the gains are incredible, and it rips fat from your abs in as little as four weeks. Your set to order your S23, but some guy in the gym advises you against it. “It causes liver hepatoxicity,” he says. “Stay away from orals; they all cause liver damage.”

With that sage advice, you suddenly don’t feel as confident about running S23. Does S23 really cause liver hepatoxicity? What is hepatoxicity anyway? The last thing you want is for your liver to pack up halfway through your cycle – that will kill your gains, and complications could take your life.

So, what’s the truth about S23 and liver hepatoxicity? In this post, we’ll give you everything you need to know about S23 and its impact on your liver.

What is hepatoxicity and why does it matter for SARMs users?

What is Hepatoxicity?

Hepatoxicity of the liver refers to damage to the organ caused by using an oral supplement or medication. When hepatoxicity occurs, it’s a sign that the liver is already undergoing significant stress, and there is a danger of severe complications arising if you don’t receive immediate treatment.

Liver hepatoxicity is easy for medical professionals to diagnose, and there are several successful treatments to resolve the condition. Fortunately, the liver is a self-generating organ and can reverse mild damage, returning to healthy function.

Common Symptoms of Liver Hepatoxicity

  • A rash on your stomach or the top of your eyelids (petechiae)
  • Stomach pains
  • Vomiting and severe nausea
  • Fatigue and fever
  • A loss of appetite
  • A dark color in your urine
  • Jaundice (a yellowing of the whites of the eyes and the skin)

If you’re experiencing any of these symptoms during any oral cycle, chances are it’s your liver crying out in distress. At this stage, it’s not possible to reverse the effect using OTC methods at home. When pain presents, get to the doctor immediately for a blood test. (1)

Your doctor will expedite the test and treat you based on your symptoms while waiting for the results. Patients in severe pain may require hospitalization to recover. Follow the advice of your doctor, and make sure you don’t use oral compounds again.

Continued liver stress can lead to the development of scar tissue on the liver. This scarring gives way to the onset of cirrhosis of the liver and liver disease.

AAS, SARMS, S23 and Liver Toxicity

S23 Liver Toxicity

SARMs get a bad rap from Anabolic Androgenic Steroids (AAS). AAS, like Dianabol, Anavar, and Winstrol, has a methylated structure, increasing liver enzyme production with repeated use. If you don’t control your dose and use the proper cycle support with AAS, it can lead to severe liver injury.

Even injectable AAS can cause severe liver distress. Testosterone and its derivatives like trenbolone, Winstrol, and Masteron all have a toxic effect on the liver. As a result of this established science, many bodybuilders and fitness enthusiasts make the mistake of thinking any oral is going to cause liver damage. (2)

The risk of liver injury associated with AAS is a well-known fact in the bodybuilding and fitness communities. However, SARMs are not AAS, and they have a different risk profile to oral and injectable steroids.

Does S23 damage the liver when consumed?

Liver Damage?

S23 is not a methylated compound with a 17-aa position like Anavar or other oral AAS. Oral AAS requires this methylation to make the drug bioavailable in the liver. However, the drawback of methylated compounds is elevated enzymes and the possibility of hepatoxicity.

S23 does not present this same issue, and users rarely report any problems associated with Liver toxicity on a cycle. However, taking large doses, sacking with other SARMs, or running the compound for extended periods over 8-weeks will have some impact on your liver.

Keep an eye out for the signs of toxicity. Discontinue use of S23 and book a consultation for diagnosis with your doctor.

Can you prevent liver toxicity from AAS and SARMs?


You can stop liver toxicity by correct management of your cycle and proper cycle support for the liver. Sticking to your dose is the best strategy to maintain the health of your liver during your cycle.

Beginners taking doses over the 10mg mark are at risk of developing more side effects than experienced users. If you’re testing the waters with S23, make sure you stick with a beginner dose. Using light doses is highly unlikely to cause liver damage, but some studies reporting even 10mg a day of SARMs can have a toxic effect. (3)

Managing your dose is the best way to avoid harm to your liver. The second strategy to prevent toxicity is to use cycle support. Cycle support typically features a supplement with beneficial ingredients that help your liver cope with the stress of processing the drugs.

Look for supplements containing the following ingredients:

  • Silymarin
  • Capparis spinosa
  • Cichorium intybus
  • Mandur bhasma
  • Solanum nigrum
  • Terminalia arjuna
  • Cassia occidentalis
  • Achillea millefolium
  • Tamarix gallica

It’s important to note that S23 has a 12-hour half-life. Therefore, you’ll have to split your dose. Don’t take your cycle support supplement at the same time as your dose. Doing so affects the absorption of the S23. Wait for 4-hours after your dose before taking your cycle support to allow the liver to absorb the S23.

Verdict & FAQ

The Verdict – is S23 liver toxic?

It’s clear that the commotion around the toxicity of S23 and SARMs, in general, is overstated. These compounds do not feature any methylation in the 17a position. Oral AAS, like Anavar and Winstrol V, along with prohormones like superdrol, can cause severe liver distress due to these compounds’ 17a position.

However, some evidence suggests that SARMs may have a toxic effect on the liver, even at small doses. The only way to be sure if you’re dealing with liver problems is through an enzyme test. Your doctor will draw blood and send it to the lad for analysis.

The results show elevations in your liver enzymes, and your doctor recommends treatment based on the extent of your condition. In general, running a liver support product alongside your SARMs cycle is ideal for mitigating the risk involved with using S23.

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What’s the best liver support for my cycle?

Milk thistle contains a compound known as silymarin. Silymarin is effective at helping the liver cope with stress. This flavonoid has a powerful cleansing effect and its readily available from plenty of online retailers. However, milk thistle comes with low bioavailability, so try to get a liquid format that promises better absorption.

How do I dose my liver support?

Silymarin does such a good job of cleansing the liver that it might take away from your dose’s efficacy if you use it alongside your S23. Therefore, it’s better to wait four hours or so after taking your S23 dose before taking your milk thistle product. This strategy ensures you have stable blood levels of S23 while keeping your liver healthy.

How do I know if my liver is damaged?

There are several signs that your liver is in distress. The most prominent physical response is the onset of “jaundice.” Jaundice turns your skin and the whites of your eyes yellow, signaling an increase in bilirubin in your bloodstream. Consuming milk thistle products might help resolve the situation, but you must stop taking S23 and see your doctor for treatment.

DISCLAIMER: The author of this content and the publishing website are not responsible for your use of SARMs. The information in this article is purely for research and entertainment purposes only. We do not endorse or recommend the use of S23 or any SARMs.

Sources Cited In This Article:

Chris Jackson
Chris Jackson

Chris Jackson, co-founder of Sarms.io, is a renowned fitness blogger, physique model, and evolutionary bioscience researcher specializing in SARMs (Selective Androgen Receptor Modulators). His extensive work, characterized by cutting-edge research and practical training advice, has made Sarms.io a leading source for accurate, credible information on performance enhancers. With a dedication to improving the understanding and application of SARMs in optimizing human performance, his contributions have not only expanded public awareness but also shaped the conversation around these substances. Chris's pursuit of knowledge and commitment to sharing it continue to inspire many in their fitness journeys.

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