4-Andro: A Complete Guide For Bodybuilding – Benefits, Side Effects, Dosage, Stacking, and more

Are you ready to dive into the new age of prohormones, where extraordinary strength meets remarkable muscle gains? Then buckle up, as we’re about to embark on a riveting journey into the realm of 4-Andro, the powerhouse behind some of the most impressive physiques in the game.

4-Andro, also known as 4-androsterone or 4-Androstene-3b-ol, 17-one or 4-DHEA, has gained popularity in the fitness world due to its potential in enhancing muscle mass, strength, and overall performance. Unlike its counterparts, it’s a non-methylated prohormone, meaning it’s easier on the liver. This has driven its popularity in the SARMs community, where many utilize it as a “test base for they cycles.

In this article, we’ll break down the ins and outs of 4 Andro, exploring its potential benefits and side effects, how it works, and how to use it effectively to maximize your gains while prioritizing your health. By the end of our 4-andro guide, you’ll be equipped with all the information you need to decide if 4-Andro is the supplement you’ve been searching for in your fitness journey.

So, whether you’re a seasoned gym-goer or a beginner stepping into the realm of bodybuilding supplements for the first time, let’s delve into the world of 4-Andro and discover if it’s the secret weapon to achieving your bodybuilding goals.

Key Takeaways
  • 4-Andro is a steroidal hormone naturally produced in both male and female gonads and the adrenal glands. It plays a vital role in the production of estrogen and testosterone. [1]
  • It is commonly used as a “test base” for stacking with other anabolic compounds.
  • It is being investigated to treat muscle wasting conditions [7]

Understanding the Basics of 4-Andro: How does it work?

4-Andro Basics

4-Andro’s primary effect is converting to testosterone, the key male sex hormone. This two-step process involves:

1. 4-Andro converts into androstenediol
2. Androstenediol then turns into testosterone

As a result, users can expect effects on par with low-dose testosterone therapy. Most notably increased muscle mass, enhanced strength, and better athletic performance. 

Notably, 4-Andro is a non-methylated prohormone, making it milder and easier on the body than methylated types. In essence, it’s less likely to harm the liver, offering a safer option for boosting testosterone levels.

Explainer diagram showing the mechanism of action of 4-Andro

Here are some of the potential benefits that users might experience when supplementing with 4-Andro:

  • Increased muscle mass: Boosts muscle growth by promoting protein synthesis and increasing nitrogen retention in muscles. 
  • Enhanced strength: Along with muscle growth, users may notice an increase in their overall strength, allowing them to push through workouts more effectively.
  • Improved athletic performance: 4-Andro’s ability to boost testosterone levels can result in enhanced physical performance, allowing athletes to compete at a higher level.
  • Support for libido: As testosterone is known to play a crucial role in maintaining a healthy sex drive, properly dosed 4-Andro supplements may also support healthy libido.

However, as with any supplement, there are potential side effects associated with 4-Andro use. Some of these might include:

  • Increased estrogen levels: Although 4-Andro itself doesn’t convert into estrogen, the resultant increase in testosterone can lead to a corresponding increase in this female hormone, which may cause side effects such as water retention and gynecomastia (breast tissue growth in men).
  • Hair loss: An increase in testosterone is also associated with an increase in dihydrotestosterone (DHT), which can contribute to hair loss. Use RU-58841 to counteract hair loss on cycle.
  • Cholesterol changes: Andro prohormones can cause alterations in cholesterol levels, potentially increasing LDL (bad cholesterol) levels and decreasing HDL (good cholesterol) levels.

How 4-Andro Benefits Athletic Performance


First and foremost, 4-Andro is a prohormone, which means it’s a compound that converts to active hormones in the body. Specifically, 4-DHEA converts to testosterone, a hormone that’s essential for building muscle mass, improving strength, and boosting energy levels. This conversion process can lead to the following benefits:

  • Increased muscle mass: Higher testosterone levels promote protein synthesis, which is crucial for building new muscle fibers. The more muscle mass you have, the stronger and more powerful you can become.
  • Enhanced strength: The conversion of 4-DHEA to testosterone can help increase overall strength, allowing you to lift heavier weights, push harder during workouts, and potentially break through plateaus.
  • Improved recovery: Testosterone plays a role in muscle recovery, aiding in the repair of muscle tissue damaged during intense workouts. Faster recovery means you can get back to training sooner, accelerating progress towards your goals.

In addition to the testosterone-boosting benefits, 4-Andro may also help with muscle protection:

  • Reduced muscle breakdown: 4-DHEA can help decrease cortisol levels, a hormone that can break down muscle tissue. By reducing cortisol, you can maintain and even increase your lean muscle mass during training. This also reduces muscle soreness following a workout.

In order to better understand the potential of 4-Andro, let’s take a look at some statistics and data from a study:

OutcomePlacebo4-Andro Group
Muscle Mass Gain0.5 kg2.1 kg
Strength Increase2.5%9.0%

As seen in the table above, the 4-Andro group experienced significantly greater gains in muscle mass and strength compared to the placebo group.

It’s important to note that these benefits may vary among individuals, and it’s crucial to follow proper dosing and cycling guidelines to ensure safe and effective usage. To fully maximize the potential of 4-DHEA, consider incorporating other factors like proper nutrition and a well-rounded training program.

Examining the Potential Side Effects and Risks

Side Effects

As with any supplement, it’s critical to understand the potential side effects and risks associated with 4-Andro. We’ll dive into some of the concerns you should be aware of when considering this prohormone.

One potential drawback is the conversion to estrogen, as it is a precursor to testosterone. This can lead to potential side effects, such as:

  • Water retention
  • Gynecomastia (breast tissue development in men)
  • Fat gain
  • Mood swings

To mitigate these side effects, some users opt for an aromatase inhibitor to block the conversion of testosterone to estrogen. However, it’s vital to consult with a healthcare professional before incorporating any additional supplements.

Another concern is the strain on the liver from oral administration. Though it’s not considered as hepatotoxic as other prohormones, liver support supplements might be a wise addition to any cycle.

Additionally, using 4-Andro may lead to a decrease in HDL (good) cholesterol and an increase in LDL (bad) cholesterol. It’s essential to monitor and maintain healthy cholesterol levels while using this prohormone.

Moreover, an increase in hair loss might occur due to the elevated levels of DHT (dihydrotestosterone) resulting from the conversion of 4-DHEA. This side effect is more likely to affect those who are genetically predisposed to male pattern baldness. You can use RU-58841 to prevent hair loss on cycle.

Lastly, it’s crucial to recognize that 4-Andro has the potential for suppression of natural testosterone production. During a cycle, it may cause the body to slow down or halt its own testosterone output. After completing a cycle, it’s highly recommended to undergo a proper post-cycle therapy (PCT) to help restore the body’s natural testosterone production.

Examining 4-Andro’s Legality in the US and Sporting

Legal Status

Over recent years, both regulations and public opinion surrounding anabolic supplements and prohormones have shifted significantly.

To understand 4-Andro’s legal status, we must discuss:

  • Federal Laws: Status in the United States and other countries
  • Sports Regulation: How andro compounds are viewed in competitive sports
  • Purchase and Consumption: Rules regarding buying and using 4-Andro

Federal Laws

In 2014, the US Congress passed the Designer Anabolic Steroid Control Act (DASCA), which aimed to regulate the anabolic steroids market by placing a number of substances on the controlled substances list. However, 4-Andro (4-DHEA) was not included in the ban. As a result, it remains legal and available for sale within the United States.

It’s essential to note that while 4-Andro is legal in the US, its legality may vary in other countries. Always check your local regulations before purchasing or consuming 4-Andro or its derivatives.

Sports Regulation

Although 4-Andro is currently legal in the US, various sports organizations have differing stances on its use. The World Anti-Doping Agency (WADA) has listed 4-Andro as a banned substance in international competitions. This means that athletes subject to WADA regulations should avoid using it to ensure they do not violate anti-doping rules.

National sports organizations and individual leagues also have their own rules, so it’s important to closely examine the guidelines of your sport before taking prohormones or SARMs.

Purchase and Consumption

As 4-Andro is presently legal for sale in the US, it can be bought from several sources, including online stores and supplement retailers. It’s available in various forms, such as capsules, tablets, and creams. To ensure the best possible results and avoid potential risks, we recommend purchasing 4-Andro from reputable vendors that have undergone third-party testing.

We recommend either Behemoth Labz or Pure Rawz. Both are members of the Verified Source Program.

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Comparing 4-Andro to Other Prohormones

4-Andro vs. 4-DHEA

Let’s dive into how 4-Andro stands against other prohormones in the market. When it comes to prohormones, there’s a wide range to choose from, and it’s essential to compare their effectiveness, safety, and legality.

One prohormone often mentioned alongside 4-Andro is 4-DHEA. While they share similarities in their chemical structures, they have some differences worth noting:

  • 4-Andro converts into testosterone in the body; on the other hand, 4-DHEA converts into 4-androstenediol, which then transforms into testosterone.
  • 4-DHEA has a lower conversion rate when compared to 4-Andro, meaning it might require a higher dosage to achieve the same benefits.
  • Both prohormones are considered safer options due to their non-methylated nature, which is less toxic to the liver compared to other methylated prohormones.

Here’s a breakdown of other popular prohormones and how they differ from 4-Andro:

ProhormonePrimary EffectNotable Differences
1-AndroIncreases lean muscle massIt’s non-aromatizing, meaning no conversion to estrogen; thus, has a lesser impact on estrogen-related side effects.
EpiandrosteroneIncreases strength and muscle hardnessIt converts into a DHT derivative instead of testosterone, which results in a different profile of effects, primarily in strength and muscle hardness.
19-Nor-DHEAIncreases strength and sizeDerivative of nandrolone, instead of testosterone; known for its joint supporting benefits and fewer androgenic side effects.

Since it’s crucial to find the right prohormone for your goals and your body’s needs, here are some factors to consider when comparing 4-Andro to other prohormones:

  • Effectiveness: 4-Andro is known for its ability to effectively boost testosterone levels in the body, resulting in increased muscle mass and overall strength.
  • Safety profile: As mentioned earlier, 4-Andro and 4-DHEA are both non-methylated compounds, making them less likely to cause liver toxicity.
  • Side effects: Some prohormones are more prone to causing side effects like hair loss, acne, gynecomastia, and increased aggression. It’s essential to weigh the pros and cons of each prohormone while considering 4-Andro.
  • Legality: Certain prohormones are banned by sports organizations and governments due to their potential health risks, while 4-Andro is a legal, safer alternative.

Properly using 4-Andro: Dosage, Cycle Length, and PCT

Cycle and Dosage

Let’s cover some key factors to consider when planning a 4-Andro cycle, including dosage, duration, post-cycle therapy (PCT), and potential side effects.

Dosage: Determining the appropriate dosage for 4-Andro depends on your fitness goals, experience level, and sensitivity to prohormones. A typical starting dose for beginners ranges from 300 to 500 mg per day. Lower dosages (100mg per day) are ideal for use as a test base.

Advanced users with experience in using prohormones may opt for a higher dose, but should not exceed 1000 mg per day.

4-Andro Dosage: How much to take for test base/standalone cycle

Duration: A standard cycle of 4-Andro generally lasts 6-8 weeks. Beginners should start with a shorter cycle of 4 weeks, while advanced users may choose to extend their cycle up to 12 weeks or beyond. Prolonged use of prohormones could lead to hormone imbalances or other issues, so it’s important to adhere to the recommended cycle length.

Post-Cycle Therapy (PCT): To help your body recover from the 4-Andro cycle and restore your natural hormone levels, PCT is crucial. We recommend beginning PCT within 24 hours of completing your cycle, and typically, a 4 to 6 week PCT phase is recommended. This should include the use of a SERM (Selective Estrogen Receptor Modulator) such as Nolvadex or Clomid, as well as a cortisol control supplement, like Ashwagandha.

4-Andro Bioavailability: Maximizing Absorption

A critical aspect of 4-Andro supplementation is its bioavailability, which refers to the rate and extent at which the active compound is absorbed into the bloodstream and becomes available for use by the body. Achieving optimal bioavailability is essential to maximizing the benefits of 4-Andro.

When taken orally, 4-Andro needs to pass through the liver’s first-pass metabolism, which may reduce the amount of active compound absorbed into the bloodstream. However, advancements in supplement delivery methods have addressed this issue in several ways:

  1. Liposomal Delivery: Liposomal technology involves encapsulating 4-Andro within a lipid layer to protect it from the first-pass metabolism of the liver, increasing its absorption and bioavailability in the body. Hi-tech pharmaceuticals offers a liposomal delivery system in their product Androdiol.
  2. Sublingual Administration: Placing 4-Andro under the tongue allows for direct absorption through the mucous membrane, bypassing the liver and entering the bloodstream more efficiently.
  3. Topical Application: 4-Andro creams and transdermal patches can be applied to the skin, allowing the compound to be absorbed directly through the skin and enter the bloodstream.

By choosing a 4-Andro supplement with enhanced bioavailability, you can increase the effectiveness of the compound, improving your potential for muscle growth, strength gains, and overall athletic performance.

Effective Ways to Stack 4-Andro


One of the most popular ways to maximize the muscle building effects of 4-DHEA is by stacking it with other compounds.

  1. Stacking with SARMs: Pairing 4-Andro with SARMs creates an incredible synergistic effect. By using 4-Andro as a “test base”, users are able to extend their SARMs cycles further than the normal 6-8 weeks. Some popular SARMs you can stack with include:

  2. Stack 4-Andro with other Prohormones: To achieve even greater gains, consider using 4-Andro alongside other popular prohormones such as:

    • 1-Andro (1 DHEA)
    • Epiandro (Epiandrosterone)

Please note: It’s important to be cautious when stacking prohormones, as they can raise the risk of side effects if not done properly.

  1. Cycle Support: Using cycle support supplements can keep your liver and cardiovascular system healthy during a 4-Andro cycle. Some useful ones are:
    • N-Acetyl Cysteine (NAC)
    • Milk Thistle
    • If high blood pressure is an issue, consider taking a beetroot supplement

Post Cycle Therapy (PCT) is essential for helping your body recover from a cycle. Some PCT supplements to consider include:

  1. Optimize Nutrition and Training: Don’t forget the basics – your diet and training are crucial for getting maximum benefits from your stack. Key points include:
    • Consume a high-protein diet and adjust total calorie intake according to your goals.
    • Incorporate a well-rounded workout plan, including both strength training and cardiovascular exercise.

When it comes to stacking 4-Andro, we can’t stress enough how vital it is to listen to your body and consult with a medical professional before starting a cycle. Always prioritize safety, and don’t be afraid to make adjustments to your stack if needed.

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Key Tips for Maximizing 4-Andro Gains

Maximizing Gains

Here are some critical tips to help you make the most of your 4-Andro gains and achieve the best possible results.

  • Proper Dosing: We recommend starting with a low to moderate dose of 4-Andro to understand how your body reacts to it. Common doses range from 300-400 mg per day, but you can increase the dosage gradually as you become more accustomed to it. Bear in mind that it’s crucial to not exceed the recommended dosage to avoid potential side effects.
  • Cycle Length: Keep your cycle length between 4-8 weeks, with an 8-week cycle being the most optimal for most users. Consistency is vital, so make sure you’re taking 4-Andro daily throughout the entire cycle.
  • Diet and Nutrition: Optimizing your diet is necessary for maximizing the benefits of 4-Andro. Consume a high-protein, moderate carbohydrate, and low-fat diet to support muscle growth and overall health. Prioritize:
    • Lean proteins (chicken, turkey, fish, lean beef)
    • Complex carbohydrates (whole grains, sweet potatoes, brown rice)
    • Healthy fats (avocado, nuts, and seeds)
  • Training Routine: Implement a comprehensive training program that targets all major muscle groups. Focus on compound exercises like deadlifts, squats, and bench presses that stimulate muscle growth. Ensure you work out a minimum of 3-4 times per week, maintaining a balance between resistance training and cardio exercises for optimal results.
  • Rest and Recovery: Giving your body ample time to recover is crucial for muscle growth. Aim for 7-8 hours of sleep per night, and consider incorporating rest days and active recovery sessions like yoga or stretching to help keep your body in peak condition.
  • Stacking 4-Andro: Stacking 4-Andro with other prohormones can increase its effectiveness. A popular choice is to stack 4-Andro with 1-Andro (1-DHEA) to achieve both muscle gain and fat loss. 

By incorporating these key tips, you’ll be well on your way to maximizing your 4-Andro gains and achieving the most impressive results.

What results can I expect from using 4-DHEA?

Expected Results

Whether you plan to bulk or cut, it’s important for us to establish realistic expectations. This can help users prevent potential disappointment and ensure that we’re using the product safely and effectively.

First and foremost, let’s remember that 4-Andro is a prohormone, not a magic pill. It may support muscle gains and improve athletic performance, but it won’t transform our bodies overnight. Consistent exercise and proper nutrition are still crucial components in achieving our fitness goals.

Typically, users have reported noticeable strength gains and increased muscle mass within a 4-8 week period of taking 4-Andro. However, results may vary depending on individual factors such as workout regimen, diet, and consistency in taking the supplement.

The following table shows some common expectations people often have when using 4-Andro:

Rapid muscle growthGradual increases in muscle size and strength; Typically within 4-8 weeks
Reduced body fat without exercise and proper dietEffective as an addition to a healthy exercise and nutritional plan
No side effectsPotential side effects; Proper dosing and cycling required to minimize risk

Keep in mind that it’s essential for us to follow the recommended dosage and cycle length while using 4-DHEA supplements. Misusing or overusing can lead to negative side effects, including hormonal imbalances and liver damage. It’s also a good idea to consult with a healthcare professional prior to starting any prohormone supplement.

Some additional factors that can help us get the most out of our 4-Andro experience include:

  • Combining it with a well-designed resistance training program and a nutrition plan tailored to our goals
  • Ensuring sufficient rest and recovery to facilitate muscle growth
  • Continually monitoring and adjusting our approach based on progress and individual responses to the supplement

Frequently Asked Questions


What is 4-Andro, and how does it work?

4-Andro, also known as 4-DHEA or 4-Androstenediol, is a prohormone that is directly converted by the body into testosterone. It does not aromatize into estrogen or convert to dihydrotestosterone (DHT) or its derivatives. When administered, 4-Andro causes a significant increase in free and total serum testosterone concentrations, leading to enhanced muscle growth and increased IGF-1 levels.

What are the benefits of 4-Andro for muscle growth?

4-Andro has been shown to stimulate muscle growth, increase IGF-1 levels, boost muscular strength, and raise serum total testosterone levels. Research has also suggested that 4-Andro can stimulate above-normal muscle growth, increase the volume of individual muscle compartments, and boost total skeletal muscle without negative impacts on sexual organs and tissues.

How does 4-Andro affect testosterone levels?

In various studies, 4 Andro has been found to significantly increase total and free testosterone levels, with a conversion rate of 15.76%, about triple that of 4-Androstenedione. The enzyme 3 β-hydroxysteroid dehydrogenase is reportedly responsible for converting 4 Andro to testosterone.

What are the differences between 1-Andro and 4-Andro?

The main difference between 1 Andro and 4 Andro is that 1 Andro is not converted to estrogen by the body, whereas 4 Andro does. The conversion rate of 4 Androstenediol to testosterone is approximately 15.76%, nearly three times that of 4-Androstenedione.

Where can I buy 4-Andro for research purposes?

Behemoth Labz is a reputable source for purchasing 4-Andro online. They provide high-quality research compounds with a 100% satisfaction guarantee, free and fast shipping, and a money-back guarantee. Behemoth Labz also carries SARMs and peptides for research purposes.

Wrapping Up Our 4-Andro Discussion


We’ve covered a lot of ground in our discussion of 4-Andro, or 4-DHEA, and its implications for those interested in its potential benefits. To recap, let’s take a brief look at some of the key points we’ve touched upon:

  • 4-Andro, also known as 4-DHEA, is a prohormone that converts to testosterone in the body
  • This compound has been gaining attention for its potential benefits in enhancing athletic performance, increasing muscle mass, and improving overall physical strength
  • As with any supplement, it’s crucial to understand the possible side effects and risks associated with 4-Andro usage; some of these may include hair loss, acne, and potential liver toxicity

In terms of possible results, it’s important to remember that individual experiences and outcomes will vary. Factors such as diet, exercise routine, and genetic predispositions play a significant role in determining how one might respond to 4-Andro supplementation. Nevertheless, some reported benefits of this compound include:

  • Increases in lean muscle mass
  • Improved strength and endurance
  • Enhanced recovery times
  • Overall improvement in physical performance
Increased muscle massHair loss
Improved strengthAcne
Enhanced recoveryPotential liver toxicity, among others

As we wrap up this discussion on 4-Andro, it’s important to emphasize the need for careful consideration and research before incorporating any supplement into your routine. Always consult with a healthcare professional to ensure that the benefits of a product like 4-Andro, or 4-DHEA, outweigh any potential risks for your unique circumstances. Keeping these factors in mind will help you make the most informed decision for your health, athletic performance, and overall well-being.


  1. Badawy, Marwa, et al. “Androstenedione (A Natural Steroid and A Drug Supplement): A Comprehensive Review Of Its Consumption, Metabolism, Health Effects, And Toxicity With Sex Differences“. Molecules, vol. 26, no. 20, 2021, p. 6210.
  2. Blystone, Chad, et al. “Toxicity and Carcinogenicity Of Androstenedione In F344/n Rats And B6c3f1 Mice“. Food and Chemical Toxicology, vol. 49, no. 9, 2011, p. 2116-2124.
  3. Broeder, Craig, et al. “Oral Andro-related Prohormone Supplementation: Do the Potential Risks Outweigh The Benefits?“. Can. J. Appl. Physiol., vol. 28, no. 1, 2003, p. 102-116.
  4. Janeczko, Anna, et al. “Mammalian Androgen Stimulates Photosynthesis In Drought-stressed Soybean“. Open Life Sciences, vol. 7, no. 5, 2012, p. 902-909.
  5. Kicman, Andrew, et al. “Effect Of Androstenedione Ingestion On Plasma Testosterone In Young Women; a Dietary Supplement With Potential Health Risks“. Clinical Chemistry, vol. 49, no. 1, 2003, p. 167-169.
  6. Lea, C., et al. “Androstenedione Treatment Reduces Loss Of Cancellous Bone Volume In Ovariectomised Rats In a Dose-responsive Manner And The Effect Is Not Mediated By Oestrogen“. Journal of Endocrinology, vol. 156, no. 2, 1998, p. 331-339.
  7. Lynch, Gordon, et al. “Strategies To Reduce Age-related Skeletal Muscle Wasting“., 2005, p. 63-84.
  8. Sahu, Saura, et al. “Validation Of Anin Vitromodel For Assessment Of Androstenedione Hepatotoxicity Using the Rat Liver Cell Line Clone‐9“. J. Appl. Toxicol., vol. 28, no. 5, 2008, p. 703-709.
  9. Taketsuru, Hiroaki, et al. “Effect Of Androstenedione On the Growth And Meiotic Competence Of Bovine Oocytes From Early Antral Follicles“. Zygote, vol. 20, no. 4, 2011, p. 407-415.
  10. Turan, Funda, et al. “Effects Of Dietary Androstenedione Concentration On Growth Of Tilapia Fry (Oreochromis Aureus Linnaeus)“. Israeli Journal of Aquaculture – Bamidgeh, vol. 59, 2007.
Chris Jackson
Chris Jackson

Chris Jackson, co-founder of Sarms.io, is a renowned fitness blogger, physique model, and evolutionary bioscience researcher specializing in SARMs (Selective Androgen Receptor Modulators). His extensive work, characterized by cutting-edge research and practical training advice, has made Sarms.io a leading source for accurate, credible information on performance enhancers. With a dedication to improving the understanding and application of SARMs in optimizing human performance, his contributions have not only expanded public awareness but also shaped the conversation around these substances. Chris's pursuit of knowledge and commitment to sharing it continue to inspire many in their fitness journeys.

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