Cardarine Side Effects – When Should You Be Worried?

It’s three weeks into your diet, and things aren’t going as you planned. You’re behind on your weight loss goals, and that stubborn fat around the love handles and glutes isn’t going anywhere. This is where Cardarine can help.

GW-501516 is a potent compound assisting physique athletes in attaining a show-stopper physique that’s hard, grainy, and vascular.

But are there Cardarine side effects to worry about? That’s what we’re unpacking in today’s article. By the end, you’ll learn how to minimize side effects wile using Cardarine and stay safe while still achieving your goals.

Let’s get into it!

What is Cardarine, and How Does It Work?

What is Cardarine

Cardarine is an interesting compound, known as a PPAR-delta activator. Also known as “Endurobol,” this SARM is a collaboration between GlaxoSmithKline and Ligand in the 90s. 

The drug’s initial use was for helping people with the treatment of metabolic disease that leads to the development of prostate and colorectal cancers.

However, the drug never made it to market, and the bodybuilding community turned onto it as SARMs gained widespread popularity and use.

  • Raise metabolic rate for faster fat burning results
  • Eliminate stubborn fat deposits
  • Enhance recovery
  • Reduce insulin resistance
  • Reduce LDL profiles for heart health
  • Enhance heart health and vascularity
  • Maintain lean muscle and reduce inflammation
  • Enhance stamina and energy levels throughout the day
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GW-501516 works on the body using two mechanisms. It binds to PPAR-delta at a cellular level, and activates cells, stimulating the genes necessary for energy production.

This effect makes Cardarine the ideal choice to add to a cutting cycle for additional support. When dieting, you’re using a caloric deficit, allowing the body to metabolize body fat for energy. However, the further you go into a diet, the more your metabolism slows due to the reduced calories.

Most people must raise the calorie limit from time-to-time using cheat meals or breaks in their dieting program. This break and introduction of more calories get the metabolism ramped up and ready for the next dieting session.

With Cardarine on your side, you don’t experience this metabolic slowdown at the six to the eight-week mark of your diet. The drug helps to keep your furnace running hot for the length of your diet.

How much Cardarine is needed to burn fat?


When starting your Cardarine cycle, the dosage you use depends on your experience using anabolic or androgenic compounds. If this is your first SARMs cycle, you need to take it easy in the early weeks. 

GW-501516 is a potent compound offering impressive results. Therefore, it’s easy to get carried away with your dose when you get such outstanding progress delivered to your doorstep with this SARM.

Start your Cardarine cycle using 10mg per day. Over the next seven to ten days, track your progress with the drug in a journal. Record your feeling of well-being, performance in the gym, and any noticeable sides.

If at day-7, you’re feeling confident, and you can feel the drug working, step up the dose by 5mg. Run this protocol for ten days, and then up the dose by 5mg again if you feel up to it. Avoid exceeding the 20mg mark, as it may start to cause complications, and sides may appear.

How long do I cycle with Cardarine?

Cycle Length

Along with your dose, the length of your cycle is an important factor for newbies to consider. For your first cycle, you should look at four to six weeks maximum. This choice of cycle length won;’ suppress your natural testosterone at the recommended dose.

Extending your cycle is not a good idea. All SARMs, even Cardarine, has a slightly suppressive effect on the Hypothalamic Pituitary Testicular Axis (HPTA). Therefore, the longer you stay on, the harder your recovery.

However, experienced users might want to extend their cycle to 8-weeks for the best results. Experienced users know the best PCT protocol for their bodies and how to recover as fast as possible from the use of these compounds. Remember to do your PCT when coming off Cardarine.

Do I need a PCT with Cardarine?

Post Cyle Therapy

Cardarine does not act on the same pathways as Anabolic Androgenic Steroids (AAS). Therefore, it does not have the same suppressive effect on testosterone production. As a result, you don’t require an extensive PCT using drugs like Nolvadex and Clomid.

However, all SARMs have some sort of impact on the CNS and the Hypothalamic Pituitary Testicular Axis (HPTA). Adding a PCT using OTC test-boosting supplements can be advantageous in speeding up your recovery.

Are there side effects associated with Cardarine use?

Side Effects

Now for the good news! According to reports, there are no know side effects from using Cardarine. Yes, that’s right, there’s nothing to be afraid of with this compound. Some will cite the research showing that Cardarine causes cancer in mice, but to date there hasn’t been ANY reported human issues. Read this post on the matter.

Cardarine is not methylated, so it doesn’t have any harmful impact on your liver like prohormones and oral AAS. There is no water retention with GW-501516, making it suitable for cutting as it doesn’t hold back any water.

The lack of water retention means there’s no elevation in your blood pressure and no risk of enlargement of the heart’s left ventricle.

It’s important to stick to the dosage guidelines when using Cardarine. Ensure you don’t exceed the maximum recommended dose for your experience, or you might start to notice mild sides appear.

Final verdict: is Cardarine worth it?

Wrapping Up

Cardarine is a useful drug for fast-tracking the results of your diet. If you’re six weeks out and lagging in your progress, Cardarine can help get you on track. It’s an effective cutting agent for the stage or the beach, and you’ll see results fast.

Cardarine is a potent SARM with little to no side effects. If you are concerned about adding it to your protocol, start with a low dose, and work your way up. It’s important to let your body recover after any SARMs cycle. Remember to complete your PCT and take the same time off as you spent on the cycle before starting a new one. 

Speak to your doctor and arrange a bloodwork panel before you start your cycle. This strategy ensures your doctor has a baseline reading of your natural homeostatic state before embarking on your chemically-enhanced journey.


Can Cardarine help me build muscle?

Cardarine helps to raise metabolic rate and boost fat burning. Therefore, most people use it in conjunction with a caloric deficit. GW-501516 can help preserve muscle mass when cutting, helping you maintain your lean muscle mass instead of watching it waste in the mirror.

Can Cardarine cause cancer?

Research shows that Cardarine promotes an environment for the growth of cancer tumors. However, there is no evidence showing that the use of Cardarine causes cancer in humans. If you’re dealing with cancer, make sure you speak to your doctor and arrange treatment, stay away from SARMs. Read my article about cardarine and cancer.

Does the FDA approve Cardarine?

Cardarine is not approved for use in humans by the FDA. GW-501516 has a classification as a “research chemical.” Therefore, it is not suitable for use in humans, much like prohormones and other muscle-building compounds.

DISCLAIMER: The hosting website and the author of this article have no onus of responsibility on how you use the information in this post. We do not condone or recommend the use of SARMs, and you use these compounds at your own risk.


  • Wikipedia – GW-501516
  • Chen W, Gao R, Xie X, Zheng Z, Li H, Li S, Dong F, Wang L. A metabolomic study of the PPARδ agonist GW501516 for enhancing running endurance in Kunming mice. Sci Rep. 2015 May 6;5:9884. doi: 10.1038/srep09884. PMID: 25943561; PMCID: PMC4421799.
  • Mitchell JA, Bishop-Bailey D. PPARβ/δ a potential target in pulmonary hypertension blighted by cancer risk. Pulmonary Circulation. 2019;9(1). doi:10.1177/2045894018812053
Chris Jackson
Chris Jackson

Chris Jackson, co-founder of, is a renowned fitness blogger, physique model, and evolutionary bioscience researcher specializing in SARMs (Selective Androgen Receptor Modulators). His extensive work, characterized by cutting-edge research and practical training advice, has made a leading source for accurate, credible information on performance enhancers. With a dedication to improving the understanding and application of SARMs in optimizing human performance, his contributions have not only expanded public awareness but also shaped the conversation around these substances. Chris's pursuit of knowledge and commitment to sharing it continue to inspire many in their fitness journeys.

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