How to Reconstitute MOTS-c for Research Purposes

Peptide research has taken the spotlight, and you’re on the front lines. You’ve got your hands on MOTS-c, a powerhouse in the world of mitochondrial-derived peptides. But before diving into your experiments, there’s a crucial step – reconstitution.

You’re about to unlock the full potential of MOTS-c. Whether you’re a seasoned researcher or a curious novice, this guide will ensure you handle the peptide like a pro. Get ready to how to reconstitute MOTS-c and propel your research forward.

Unlocking the Secrets of This Mitochondrial-Derived Peptide and Its Implications for Health

What Is MOTS-c Peptide?

MOTS-c, short for Mitochondrial-Derived Peptide C, is one of the many bioactive peptides hidden within your body’s cells that are pivotal to maintaining metabolic homeostasis. Discovered not too long ago, this peptide has quickly gained traction in the field of biochemical research due to its unique origin and functions.

Mitochondria, often referred to as the powerhouse of your cells, go beyond just energy production—they also play a crucial role in signaling pathways. MOTS-c is encoded within the mitochondrial DNA which makes it distinctive from most other peptides coded in the nucleus.

Here’s a visual guide showing how MOTS-c works in the body:

Once your reconstitute MOTS-c for use, you can begin to experience the benefits outlined in this chart

Packed with potential, MOTS-c has been associated with various beneficial effects, such as regulation of metabolism, enhancing insulin sensitivity, and even exercising influence over body weight. Its ability to help protect against metabolic disorders places it at the forefront of research into treatments for conditions like obesity and type 2 diabetes.

Beyond its metabolic prowess, early studies suggest that MOTS-c might also possess the ability to modulate cellular stress responses. This adds another layer to its already impressive profile, solidifying its value in therapeutic research.

Considering its mitochondrial origin, it’s no wonder that you’re curious about how to harness and study the powers of MOTS-c. Proper reconstitution is key to ensuring that you’re working with a stable and effective form of the peptide. Moving forward, let’s dive into the specifics so you can utilize MOTS-c to its full potential in your experiment.

Ensuring Precision and Efficacy with Proper Reconstitution Techniques

How to Reconstitute MOTS-c

Step 1: Gather Ingredients and Equipment

Before you begin, make sure you’ve got all your bases covered. You’ll need sterile vials, bacteriostatic water, and of course, the MOTS-c peptide. Don’t forget precision tools like a syringe and alcohol wipes – they’re crucial for ensuring sterility and accuracy. Create a clean workspace to operate in; this isn’t just good practice, it’s a game changer for successful peptide reconstitution.

Step 2: Measure the Bacteriostatic Water

Precision is key, so get your syringe ready. Draw the necessary amount of bacteriostatic water carefully, double-checking the measurement. The volume of water you use will depend on the concentration required. More water means a more diluted peptide solution, so tailor this step to your experiment’s needs.

💡 Pro Tip: Use our Peptide Dosage Reconstitution Calculator to calculate exactly how much solution to add to your vial.

Step 3: Mix the Mots-C and Bacteriostatic Water

Now for the main event: reconstituting MOTS-c. Take your vial of lyophilized peptide and gently inject the bacteriostatic water. But here’s the kicker – you’ll want to aim the stream of water against the glass, not directly onto the peptide powder. This helps prevent degradation and ensures a more gentle reconstitution.

Step 4: Swirl to Mix

Patience is your best friend in this last step. Swirl the vial to encourage the powder to dissolve – and remember, never shake. Shaking can damage the delicate structure of the MOTS-c peptide. Be gentle, and you’ll get a perfectly mixed solution ready for your research needs. Keep an eye out for undissolved particles – a clear solution indicates you’ve done it right.

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Wrapping Up: Final Thoughts on Reconstituting MOTS-c


You’re now equipped with the know-how to reconstitute MOTS-c effectively. By following the steps outlined, you’ll ensure the integrity of the peptide and the validity of your research outcomes. Remember, precision and a gentle hand are your best tools in this process. With your solution ready, you’re set to move forward in your scientific endeavors, confident in the knowledge that you’ve prepared your MOTS-c with the utmost care.


  1. Cataldo, L., Fernández-Verdejo, R., Santos, J., & Galgani, J. (2018). Plasma mots-c levels are associated with insulin sensitivity in lean but not in obese individuals. Journal of Investigative Medicine, 66(6), 1019-1022
  2. D’Souza, R., Woodhead, J., Hedges, C., Zeng, N., Wan, J., Kumagai, H., … & Merry, T. (2020). Increased expression of the mitochondrial derived peptide, mots-c, in skeletal muscle of healthy aging men is associated with myofiber composition. Aging, 12(6), 5244-5258.
  3. Gao, Y., Wei, X., Wei, P., Lu, H., Zhong, L., Tan, J., … & Liu, Z. (2023). Mots-c functionally prevents metabolic disorders. Metabolites, 13(1), 125.
  4. Jiang, J., Chang, X., Nie, Y., Shen, Y., Liang, X., Peng, Y., … & Chang, M. (2021). Peripheral administration of a cell-penetrating mots-c analogue enhances memory and attenuates aβ1–42- or lps-induced memory impairment through inhibiting neuroinflammation. Acs Chemical Neuroscience, 12(9), 1506-1518.
Chris Jackson
Chris Jackson

Chris Jackson, co-founder of, is a renowned fitness blogger, physique model, and evolutionary bioscience researcher specializing in SARMs (Selective Androgen Receptor Modulators). His extensive work, characterized by cutting-edge research and practical training advice, has made a leading source for accurate, credible information on performance enhancers. With a dedication to improving the understanding and application of SARMs in optimizing human performance, his contributions have not only expanded public awareness but also shaped the conversation around these substances. Chris's pursuit of knowledge and commitment to sharing it continue to inspire many in their fitness journeys.

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