Enclomiphene vs Clomid: Which SERM is Best For Boosting Testosterone in TRT and PCT?

Navigating the world of testosterone supplementation can certainly be a challenge. We’re here to shed some light on the comparison between enclomiphene vs clomid for boosting testosterone levels. These compounds, often used interchangeably, have distinct characteristics that set them apart. We’re going to delve into these differences and provide you with the necessary knowledge to make an informed decision about which might be the best choice for your situation.

Our comprehensive dive into the world of clomid, found here, and our detailed exploration of enclomiphene, available here, provide significant background knowledge on these intriguing compounds. Clomid and enclomiphene share similarities as selective estrogen receptor modulators (SERMs), but they’re not identical twins. We’ll investigate the nuances that differentiate them, particularly when it comes to their efficacy in testosterone boosting and improving reproductive health.

Contrary to popular belief, these aren’t just two different names for the same thing. Their small structural differences can lead to substantial variations in physiological responses. We’re going to dissect these differences, how they impact the body, and why one may be a more sensible choice than the other for testosterone enhancement purposes. By the end of this article, you’ll be armed with the knowledge to make a decision based on facts, not just hearsay and speculation.

Key Takeaways
  1. πŸ’Š Enclomiphene and Clomid are drugs used to stimulate testosterone production and aid fertility.
  2. πŸ†• Enclomiphene citrate is a newer and less established SERM. It is more selective in action, causing fewer side effects, and some studies suggest it’s more efficient at boosting luteinizing hormone (LH) and follicle-stimulating hormone (FSH).
  3. πŸ’’ Clomid is known to produce more side effects, while enclomiphene might lead to fewer side effects and higher testosterone levels.
  4. πŸ”„ Clomid contains two isomers, one beneficial and one causing side effects. Enclomiphene contains only the trans-isomer, which positively impacts testosterone production.
  5. 🚻 Both drugs are effective for fertility and testosterone boost, with availability and individual needs determining the choice. Clomid is cheaper, but enclomiphene may yield better results.

Understanding Testosterone Replacement Therapy


Testosterone replacement therapy (TRT) is gaining popularity as a strategy to counter low testosterone levels. As we dive deeper into this topic, two medications emerge as front-runners: Enclomiphene and Clomid.

To boost testosterone levels, both Enclomiphene and Clomid stimulate the hypothalamus and pituitary gland, which then prompt the testes to produce testosterone.

Testosterone Production ProcessEnclomipheneClomid
Stimulates HypothalamusYesYes
Causes Pituitary Gland to Release HormonesYesYes
Prompts Testes to Produce TestosteroneYesYes

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While it’s true that both options stimulate testosterone production, there are notable differences to consider.

Clomid, also known as clomiphene, has been on the market longer and is more commonly prescribed. It’s well-established, trusted, and used for treating both low testosterone and infertility in men. Nevertheless, Clomid doesn’t come without drawbacks. It’s known to cause certain side effects such as mood swings, dizziness, and visual disturbances, which for some men might outweigh the benefits.

Enclomiphene citrate, on the other hand, is the newer kid on the block. Though not as established, it showcases promising results for increasing testosterone levels and fertility. The key upside to Enclomiphene is that it remains more selective in its action, meaning it potentially results in fewer side effects than Clomid. Furthermore, some studies suggest that Enclomiphene may be more efficient in boosting LH and FSH – the two building blocks of testosterone.

  1. Luteinizing Hormone (LH): LH is produced and released by the pituitary gland located in the brain. When LH is released, it signals the Leydig cells in the testes to produce and release testosterone. In this way, LH primarily regulates testosterone production.
  2. Follicle-Stimulating Hormone (FSH): FSH, also produced by the pituitary gland, primarily targets the Sertoli cells in the testes. FSH encourages these cells to facilitate the maturation of sperm. However, FSH also stimulates the production of androgen-binding protein, which helps maintain high levels of testosterone within the testes to support this sperm maturation process.

Together, LH and FSH coordinate to ensure healthy levels of testosterone and effective sperm production, thereby playing a significant role in male fertility and the maintenance of secondary sexual characteristics. Here’s a diagram showing how it works:

Diagram showing the role of Luteinizing Hormone and Follicle Stimulating Hormone in the body

In the next sections, we’ll delve into the particularities of Enclomiphene and clomid in more depth, drawing out their unique aspects and comparing them in different ways. So, keep reading!

The Role of Enclomiphene in Boosting Testosterone

Understanding Enclomiphene

Let’s discuss how Enclomiphene works to increase testosterone levels. By understanding this, you’ll begin to see why it’s being touted as such a promising drug for conditions like hypogonadism and testicular atrophy.

Enclomiphene, unlike clomid, is composed of pure trans-isomer. This is a key difference that has significant impacts on how our bodies respond to treatment. It’s this trans-isomer that directly impacts the hypothalamic-pituitary-testicular axis, thus influencing testosterone production.

  • Enclomiphene works by inhibiting the negative feedback loop in our body’s hormone regulation process.
  • As estradiol levels are suppressed, the body produces more luteinizing hormone (LH) and follicle-stimulating hormone (FSH).
  • These hormones then stimulate the testes to produce more testosterone.

In contrast, clomid contains both trans and cis-isomers. While the trans-isomer increases testosterone production, the cis-isomer has the opposite effect. This dual effect can lead to a plateau in testosterone production – an outcome not typically seen with enclomiphene.

Clinical trials provide supportive evidence on enclomiphene’s effectiveness. A notable one being a study conducted in 2013, where men receiving 25mg of enclomiphene demonstrated an increase of 56% in serum testosterone levels within the first 6 weeks. On the other hand, men receiving the same dosage of clomid only reported a 37% increase.

Study GroupSerum Testosterone Increase (%)

It’s clear that when it comes to increasing testosterone production, enclomiphene packs a punch. While clomid has its advantages, enclomiphene’s unique composition and resulting effects place it in a league of its own. This is why we can’t emphasize enough on the importance of understanding the differences between the two when considering treatment options.

Clomid’s Impact on Testosterone Production

Understanding Clomid

Navigating the landscape of hormone production and testosterone enhancement involves many twists and turns. Clomid’s impact on testosterone production is an area in which we are particularly interested. Traditionally, clomiphene citrate has been used to treat fertility issues in women. 

It formidably boosts the body’s natural testosterone production. However, let’s not neglect its simultaneous effects on estrogen levels.

See, Clomid stimulates both the release of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). This stimulates your testes. Not only do you get a good kick of testosterone production, but these hormones also trigger the release of estrogen. The free circulating estrogen kickback is the main reason people often complain of low libido while taking Clomid.

Diagram showing how LH and FSH are important for building muscle mass and distributing fat.
Testosterone Production EffectHighHigh
Estrogen Production EffectHighLow

Clomid is comprised of two isomers – enclomiphene and zuclomiphene. An isomer is a compound with the same molecular formula as another compound, but with a different chemical structure.

  1. Enclomiphene: This isomer is primarily responsible for the therapeutic effects of Clomid, namely the stimulation of testosterone production. It does this by acting as an antagonist at estrogen receptors in the hypothalamus, which essentially tricks the body into thinking it has low estrogen levels. This causes the hypothalamus to release more GnRH (gonadotropin-releasing hormone), which in turn stimulates the pituitary gland to produce more FSH and LH, leading to increased testosterone production and sperm maturation.
  2. Zuclomiphene: While it is structurally similar to enclomiphene, zuclomiphene functions differently in the body. It tends to have a longer half-life and has more estrogenic effects. This isomer is often associated with many of the side effects that can occur with Clomid use, such as visual disturbances, mood swings, and nausea. This is because zuclomiphene remains in the body longer and can cause the body to react as if it has higher estrogen levels.
  • Clomid: substantially enhances testosterone, may increase estrogen.
  • Enclomiphene: enhances testosterone, does not notably increase estrogen.

Comparing Enclomiphene and Clomid: Effects, Side Effects, and Efficacy

Enclomiphene vs Clomid

Let’s dive into a side-by-side comparison of these two compounds, focusing on their effects, the side effects, and their efficacy.

Enclomiphene’s winning edge lies in its ability to boost testosterone production. By analyzing blood tests, we’ve found that this isomer triggers significantly higher testosterone levels when compared with Clomid. Here’s how they stack up:

Testosterone increaseHighModerate

But you’re probably wondering, does this come with any side effects? Well, Enclomiphene’s deleterious outcomes are relatively low. Of course, there’s the common sensation of hot flashes and occasional headaches. But Clomid has its fair share as well – headache, dizziness and ocular disturbances are among its most notorious offenders.

Diving deeper into the side effects, it’s worth noting a unique aspect:

  • Enclomiphene – minimal impact on mood.
  • Clomid – can sometimes induce mood swings.

Efficacy-wise, it’s a close call. Both Enclomiphene and Clomid show considerable success in maintaining fertility and raising testosterone levels. For some men, Clomid might work better, particularly in terms of fertility. While others swear by the testosterone boosting capabilities of Enclomiphene.

So, what’s the bottom line? Enclomiphene and Clomid are two potent alternatives that can be tailored to match your individual situation. They are different tools in the toolbox, and the key is finding what fits best for you.

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Drawing Conclusions: Enclomiphene vs. Clomid for Testosterone


As our exploration into the comparison between enclomiphene and clomid for boosting testosterone levels concludes, it’s clear both substances have potential benefits and downfalls. Let’s dive into some of the unique aspects of each.

Evaluating these substances from a side effect perspective, it’s worth noting that enclomiphene appears to have an edge over clomid. This advantage is primarily owing to the decrease in visual disturbances – a common adverse reaction associated with clomid usage.

Effectiveness in raising testosterone is another major comparison point. Studies have indicated that both enclomiphene and clomid can significantly boost testosterone levels. However, users report anecdotally that enclomiphene delivers more consistent results, meaning it could be a more reliable choice for long-term use.

Looking at their impact on fertility, again, both agents show promise. They help increase sperm count, allowing those struggling with fertility issues a better chance at conception. Nevertheless, research suggests that clomid may offer slightly more significant improvements in this area, which could tip the scales in its favor for those primarily seeking fertility enhancement.

And finally, the accessibility of these substances is a crucial consideration. While clomid is widely available and typically more affordable, enclomiphene is not as easy to acquire and can be more costly. This accessibility factor could influence your SERM choice depending on personal budget constraints and location.

To sum it all up:

  • Enclomiphene tends to have fewer side effects, especially regarding visual disturbances.
  • Both substances significantly boost testosterone, with enclomiphene providing more potent results.
  • Although both aid fertility, clomid potentially has a slightly greater impact on sperm motility.
  • Clomid is more readily available and generally cheaper than enclomiphene.

So there we have it. While it’s clear both enclomiphene and clomid have their merits when it comes to testosterone enhancement and fertility improvement, your unique situation and requirements will ultimately dictate the better fit for you.

Frequently Asked Questions


What is the difference between enclomiphene and Clomid?

While both are linked to enhancing fertility, enclomiphene is an isomer found in Clomid that specifically works to stimulate ovulation. Clomid, however, also contains the isomer zuclomiphene which can cause side effects.

How does enclomiphene bind to receptors in the body?

Enclomiphene binds to estrogen receptors in the brain, particularly the hypothalamus, which then boosts the release of hormones that induce ovulation.

Can enclomiphene be used in steroid cycles?

Yes, enclomiphene can be used during post cycle therapy (PCT) in steroid cycles to help restore natural testosterone production, though always under medical supervision.

How does enclomiphene stimulate ovulation compared to Clomid?

Enclomiphene, a key isomer in Clomid, stimulates ovulation by triggering the brain to release fertility-enhancing hormones. The presence of zuclomiphene in Clomid is the primary reason for side effects.

Does enclomiphene influence igf-1 levels?

Enclomiphene may indirectly affect igf-1 levels since it impacts testosterone and estrogen balance. More research, however, is required to validate this claim.

Is enclomiphene a steroid or a peptide?

Enclomiphene is neither a steroid nor a peptide. It’s a selective estrogen receptor modulator (SERM) used to stimulate ovulation in females and raise testosterone in men.

Can you take enclomiphene without Clomid?

Yes, enclomiphene can be administered separately from Clomid to potentially limit side effects, but this should always be under the guidance of a healthcare provider.


  1. Agrawal, K., et al. “Ovulation Induction Using Clomiphene Citrate Using Stair – Step Regimen Versus Traditional Regimen In Polycystic Ovary Syndrome Women – a Randomized Control Trial”. J Hum Reprod Sci, vol. 10, no. 4, 2017, p. 261.
  2. Brown, Janine, et al. “Characterization Of the Effects Of Clomiphene Citrate On Reproductive Physiology In Male Rats Of Various Ages“. Acta Endocrinologica, vol. 118, no. 3, 1988, p. 437-443.
  3. C.H, Haris, et al. “A Comparative Study To Assess the Effect Of Testicular Vein Ligation Followed By Six Months Course Of Clomiphene Citrate And Testicular Vein Ligation Alone In Patients Presenting With Infertility And Varicocoele“. jebmh, vol. 4, no. 75, 2017, p. 4404-4407.
  4. Gupta, Mahesh, et al. “Clomiphene Citrate: the Changing Landscape“. Int J Basic Clin Pharmacol, vol. 7, no. 8, 2018, p. 1437.
  5. Nelson, Elizabeth, et al. “Clomiphene and Its Isomers Block Ebola Virus Particle Entry And Infection With Similar Potency: Potential Therapeutic Implications“. Viruses, vol. 8, no. 8, 2016, p. 206.
Chris Jackson
Chris Jackson

Chris Jackson, co-founder of Sarms.io, is a renowned fitness blogger, physique model, and evolutionary bioscience researcher specializing in SARMs (Selective Androgen Receptor Modulators). His extensive work, characterized by cutting-edge research and practical training advice, has made Sarms.io a leading source for accurate, credible information on performance enhancers. With a dedication to improving the understanding and application of SARMs in optimizing human performance, his contributions have not only expanded public awareness but also shaped the conversation around these substances. Chris's pursuit of knowledge and commitment to sharing it continue to inspire many in their fitness journeys.

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