Melanotan II Guide for Safe and Effective Tanning

If you’re looking to get that sun-kissed glow without the harmful effects of sunbathing, Melanotan II might be just what you need. It’s a tanning injection that promises quicker, long-lasting results. But there’s more to it than just injecting and waiting for a tan to develop.

Before you start, it’s vital to know your skin type and understand how Melanotan II works. This guide will help you navigate the ins and outs of using Melanotan II effectively. You’ll learn how to avoid unwanted side effects, the importance of UV exposure in the process, and how to be patient while waiting for your desired results.

So, whether you’re a skin type I or II individual, or just curious about the world of tanning injections, dive in to discover how to get the most out of your Melanotan II experience.

What is Melanotan II and what does it do?

Melanotan II Explained

Melanotan II is a lab-created chemical with strong resemblances to a hormone that naturally occurs in people. You might see it cropping up on various social media platforms where some influencers are hyping its tanning capabilities.

But wait – it’s not quite that straightforward. Interestingly, Melanotan II operates through the mimicry of melanocortin peptides. These cutting-edge peptides play a significant role in your body’s pigmentation, energy homeostasis, sexual functioning, immune system, inflammation response, and cardiovascular system.

Just like Melanotan I, this second edition acts as a stimulant for the production of eumelanin. That’s a mouthful, right? Essentially, it encourages your skin to darken. This is called tanning – sound familiar?

How does Melanotan II work?

How it Works

A key aspect to understand is the function of Melanotan II in your body. This lab-synthesized peptide resembles a hormone naturally found in the human body known as “melanocyte-stimulating hormone.” Let’s jump deeper into its workings. First, here’s a chart showing how Melanotan 2 works in the body:

How Melanotan II works in the body (flowchart)

Activation of Melanocyte Receptors

Melanotan II operates chiefly through the activation of certain melanocortin receptors within your body. Specifically, it targets MC-1R receptors which are responsible for signaling the body to produce more melanin. This connection induces several effects, including the darkening of skin and hair. Beyond MC-1R, there are four more types of melanocortin receptors, each with different impacts on the body. For instance, MC-3R regulates appetite and energy while MC-4R influences sexual behavior and erectile function. The versatile and multi-faceted workings of Melanotan II have led to its association with other effects such as increased libido and decreased body fat levels in test subjects.

Increased Production of Melanin

Once activated by Melanotan II, these melanocyte receptors stimulate the production of more melanin. This process naturally darkens the skin, giving you a sun-kissed glow. Note, however, that Melanotan II does not work without exposure to UV light. It’s vital you get at least 20 minutes of natural sunlight a day to help activate the Melanotan II injections.

Melanotan II has been linked to the α-MSH hormone, a significant player in determining skin and hair pigmentation. By escalating the production of melanin in the skin, the end result is more than just a superficial tan. It leads to a “sunless tan” that appears naturally rather than artificially induced.

Your skin might not respond to Melanotan II instantly, especially if you belong to the skin type I category. Patience is recommended. It might take weeks or even months to achieve the desired results.

Findings from initial research undertaken in the 1980s using alpha-melanocyte stimulating hormone (MSH) analogues indicated that these compounds triggered melanocytes to make more eumelanin. One of these analogues, Afamelanotide, potentiated the tanning effects of UV light exposure and reduced sunburns and thymine dimer formation. This research led to further interest in analogues like Melanotan II and its potential dermatological applications.

Finally, remember Melanotan II has not been fully tested for all its potential side effects. Make sure to report any negative effects to the FDA or suitable health bodies in your country.

What are the benefits of using Melanotan II?


Below we’ll delve into the potential benefits of Melanotan II and how, despite being in the research phase, it’s being applied in various sectors.

Enhanced Tanning

Talk about a beauty hack! Melanotan II is enticing users with the promise of a sunless tan. This lab-made chemical stimulates melanin production, the pigment that darkens your skin, giving you that desired golden glow. But we’re not just talking a regular tan, Melanotan II brings about tanning at an accelerated pace, a feature particularly appreciated by athletes and fitness enthusiasts.

Reduced Sunburn Risk

Nothing hampers summer fun quite like a sunburn. Those blistering, red patches of skin aren’t just painful, they’re harmful too. Suffering one or more severe sunburns in your childhood may double the chances of developing melanoma in later life. Enter Melanotan II. Early studies suggest this peptide may protect skin from sun damage and possibly reduce your chance of getting skin cancer. While Melanotan II can’t completely replace your broad-spectrum sunscreen, it could potentially add an extra layer of defense against the sun’s harmful UV rays.

Boost in Libido

The original intent behind the development of Melanotan II may surprise you. It was first explored as a treatment for hypoactive sex drives in both male and female test subjects. Now, several studies have linked Melanotan II to increased libido, highlighting its potential as a libido-boosting agent. Once again, we advise caution, as there are no approved dosages or safety guidelines for humans at this point.

Remember, the FDA has warned against the use of Melanotan II and other synthetic analogues, and any potential benefits should be weighed against the lack of complete testing and potential side effects. Always prioritize safety and consult a healthcare professional before deciding to use products like Melanotan II.

How to properly dose and use Melanotan 2

Dosage & Use

As an artificial hormone created in the lab, Melanotan II has a complex process of administration, particularly when it’s linked with potential health concerns. It’s crucial to stress that the use of Melanotan II is still in its research phase. Despite its promising potential benefits, it’s by no means a commercially available product endorsed by FDA or similar bodies.

Dosage and Administration

Melanotan II dosing works on a start-small-and-build-up approach. If you’re planning to use it, start with a dose of around 0.25mg and gradually escalate to a maximum dose of 1mg. This progressive method allows your body to acclimate to the effects of Melanotan II. In terms of how often you should take it, early usage guidelines suggest an initial three to four days of micro-dosing at 0.05ml, especially if you have a low tolerance level.

Studies indicate that the most common dosage amount used is 500mcg. Thankfully, dosage calculation isn’t as complicated as it sounds. The calculation requires attention to detail and precision. Once you get it right, maintaining the dosage isn’t as daunting. Remember to use a syringe and measure carefully. Injections can be made directly into the fat layer beneath the skin at a 90-degree angle.

Preparing the Injection

So, you’ve calculated and ready to go! But before getting started with injections, note that Melanotan II comes in powdered form and requires appropriate handling and preparation.

To create the solution, mix Melanotan II with bacteriostatic water. Injection preparation also requires clean practices to maintain sterility. Start by wiping your Melanotan stopper, then insert the syringe and withdraw the required dose. Make sure the needle immerses in the solution before drawing back. Always double-check for air bubbles in the syringe before continuing, these can be removed by tapping the syringe gently.

Injection Technique

When it comes to the injection process, it’s important to inject securely into a clean site. Proper technique is a crucial aspect of ensuring effective absorption and minimizing potential discomfort.

The process is straightforward: pinch a small fold of skin and insert the needle at a 90-degree angle, then slowly push on the syringe’s plunger until its base is reached. Make sure to rotate the injection site each time to prevent scarring and discomfort.

After the injection, return the remaining solution back to your refrigerator for future use. Typically, it’s recommended to consult a professional if the prospect of self-injection is daunting. Keep close track of your experiences while using Melanotan II and always remember, safety should be your utmost priority.

Potential side effects of Melanotan II usage

Side Effects

Even though most people don’t experience side effects, it does carry risks that you must be aware of. Here we’ll dive deeper into a few noteworthy reactions such as nausea and vomiting, facial flushing, and increased pigmentation.

Nausea and Vomiting

When using Melanotan II, you may experience Nausea and Vomiting. A common reaction, it often accompanies spontaneous erections and increased libido. To manage nausea try lower doses of the drug – often times, less is more. Along with nausea, weight loss may occur due to appetite suppression. But don’t get ahead of yourself, these aren’t symptoms you’d want to induce intentionally for weight loss purposes.

Facial Flushing

Another known effect is Facial Flushing. This occurrence usually happens upon the administration of Melanotan II. It’s coupled with flu-like symptoms and increased blood pressure. It’s important to monitor your health closely when dealing with changes in blood pressure. Melanotan II is nothing to take lightly – your health comes first.

Increased Pigmentation

One of the primary expected effects of Melanotan II is Increased Pigmentation but it doesn’t come without risks. More than just giving you a more tanned appearance, Melanotan is known to darken moles and cause an increased number of freckles. Worst-case scenario – it can stimulate dangerous changes in the skin. Reports of moles rapidly changing and becoming darker have been recorded. And remember, no tan can effectively protect skin from the sun’s damage, not even the ones induced artificially.

This emphasis on understanding the potential effects of Melanotan II is not meant to scare you but rather to keep you informed and ahead of what might come. Treat it with respect and, as with all things in life, moderation is key.

Where to buy legit Melanotan II online

Buy Online

Wondering where to purchase Melanotan II for your research needs? A top-notch vendor should be your primary concern, offering high standards of product quality, transparency, and customer service.

Sports Technology Labs

Head on over to Sports Technology Labs! This vendor is known for their strict sourcing guidelines – all of their peptides are synthesized right here in the USA. I’ve been using them for a while and I definitely recommend this source.

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Frequently Asked Questions


How to use Melanotan 2 for tanning?

To use Melanotan 2, take the vial containing 10mg of Melanotan II peptide, mix MT2 with 1ml of sterile water, and then take the tan nasal spray or subcutaneous tanning injections to introduce it to your body. Use an online Melanotan 2 dosage calculator to decide the perfect dosage according to your body weight. Don’t overlook sun exposure and tanning bed use since Melanotan 2 works synergistically with it.

How to calculate the correct Melanotan 2 dosage?

Traditionally, if you have a 10mg vial of Melanotan 2 and use 1ml of water to mix MT2, every 0.1 by the 10ml tick mark of the syringe corresponds to 1mg. But the best way to calculate the most sensible and safe dosage scheme for your needs is by using an online dosage calculator.

I have a Melanotan 2 tanning nasal spray. How to use it?

When you are ready to use melanotan 2 in nasal spray form, take the nasal spray container, remove the yellow cap, and then administer it nasally by pressing on the tip. Like injections, the dosage will also depend on your body weight, so use a dosage calculator to figure out the correct amount.

How to mix MT2 in a vial?

After taking a vial containing 10mg of Melanotan, you would take your swab, wipe the top of the vial, take 1ml sterile water and slowly introduce it into the vial from the side of the vial, let it fully dissolve, then you’re ready for the injections or the nasal spray.

What are potential Melanotan 2 side effects?

Melanotan 2 side effects may include nausea, facial flushing, appetite loss, and increased sex drive. However, majority side effects occur less frequently as the body adapts to the peptide. Anyhow, if side effects persist or if you are worried, consult with your physician.

Is there any connection between Melanotan 2 and erectile dysfunction treatment?

Yes, Melanotan II peptide was actually first synthesized with the aim of treating erectile dysfunction. Besides its effects as a sunless tanning agent, male users frequently report increased sex drive. Yet, it’s important to note that this is not its intended and primary use and it has not been fully approved as a treatment for erectile dysfunction.

Can I use Melanotan 2 tanning nasal spray instead of tanning injections?

Sure, Melanotan 2 is available both in injection and nasal spray form. The nasal spray method is only effective up to 30 – 40% because the nasal method is not a direct and is not as effective as the direct injection method due to the molecule not being able to adequately penetrate the nasal membranes. But it’s a more appealing option for those afraid of needles.

How to store Melanotan 2 vials?

Pure Melanotan 2, before being mixed with the sterile water, should be stored in a cool dry place like your refrigerator. Once mixed with sterile water, the solution should be kept in the refrigerator and used within a few weeks.

When will I see tanning effects after using Melanotan 2?

Within a week of consistent daily use, you should notice a change in your skin color. After using the dosage for about two weeks, a warm and rich tan can be achieved. Remember, Melanotan 2 works synergistically with actual sunlight or a tanning bed, so the process is affected by factors like your skin type and time spent under UV rays.

How often to take Melanotan 2 tanning injections?

The frequency of administering Melanotan 2 will depend on your initial skin color, body weight and desired result. Traditionally, people start with a dose of 0.5mg a day, slowly increasing to 1mg a day, reducing the frequency once the desired pigmentation level has been reached. The exact dosage should be calculated with a Melanotan 2 dosage calculator to decide the most effective dosage for your body.

Wrapping up: final thoughts on this tanning peptide


You’ve now journeyed through the essential guide to using Melanotan II. Armed with knowledge on dosage, administration, and the importance of professional consultation, you’re well-equipped to approach this product with a safety-first mindset. Remember, moderation and caution are key when dealing with substances like Melanotan II.

You’ve also learned about potential side effects to watch out for. It’s crucial to listen to your body and seek medical advice if needed.

Lastly, you’ve been introduced to Sports Technology Labs, a trusted vendor that values quality, transparency, and customer service. So, when you’re ready to purchase Melanotan II, you know where to go.

Remember, the journey doesn’t stop here. Continue to educate yourself, stay safe, and enjoy the benefits of Melanotan II responsibly.


  1. Cai, M. and Hruby, V. (2016). Design of cyclized selective melanotropins. Biopolymers, 106(6), 876-883.
  2. Dreyer, B., Amer, T., & Fraser, M. (2019). Melanotan-induced priapism: a hard-earned tan. BMJ Case Reports, 12(2), e227644.
  3. Hatziieremia, S., Kostomitsopoulos, N., Balafas, V., & Tamvakopoulos, C. (2007). A liquid chromatographic/tandem mass spectroscopic method for quantification of the cyclic peptide melanotan‐ii. plasma and brain tissue concentrations following administration in mice. Rapid Communications in Mass Spectrometry, 21(15), 2431-2438.
  4. Li, G., Zhang, Y., Wilsey, J., & Scarpace, P. (2004). Unabated anorexic and enhanced thermogenic responses to melanotan ii in diet-induced obese rats despite reduced melanocortin 3 and 4 receptor expression. Journal of Endocrinology, 182(1), 123-132.
  5. Navarro, M., Lerma-Cabrera, J., Carvajal, F., Lowery, E., Cubero, I., & Thiele, T. (2011). Assessment of voluntary ethanol consumption and the effects of a melanocortin (mc) receptor agonist on ethanol intake in mutant c57bl/6j mice lacking the mc‐4 receptor. Alcoholism Clinical and Experimental Research, 35(6), 1058-1066.
  6. Peters, B., Hadimeri, H., Wahlberg, R., & Afghahi, H. (2020). Melanotan ii: a possible cause of renal infarction: review of the literature and case report. Cen Case Reports, 9(2), 159-161.
  7. Wessells, H., Fuciarelli, K., Hansen, J., Hadley, M., Hruby, V., Dorr, R., … & Levine, N. (1998). Synthetic melanotropic peptide initiates erections in men with psychogenic erectile dysfunction: double-blind, placebo controlled crossover study. The Journal of Urology, 160(2), 389-393.
Chris Jackson
Chris Jackson

Chris Jackson, co-founder of, is a renowned fitness blogger, physique model, and evolutionary bioscience researcher specializing in SARMs (Selective Androgen Receptor Modulators). His extensive work, characterized by cutting-edge research and practical training advice, has made a leading source for accurate, credible information on performance enhancers. With a dedication to improving the understanding and application of SARMs in optimizing human performance, his contributions have not only expanded public awareness but also shaped the conversation around these substances. Chris's pursuit of knowledge and commitment to sharing it continue to inspire many in their fitness journeys.

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